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Study of Vac a Genotypes of H.Pylori Isolated From Patients With the Upper Gastrointestinal Diseases by Pcr



Havaei SA1 ; Salehi R2 ; Fazeli SA1 ; Tavakkoli H3 ; Mohajeri P4
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Cell Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of gastroenterology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Journal of Isfahan Medical School Published:2009

Abstract

Background: Helicobacter pylori (H. pylori) is a gram negative curved bacilli colonized in the human stomach. It causes duodenal ulcer, gastritis and is associated with adenocarinoma. There might be a possible relationship between cagA, vacA and ice a genes and clinical outcomes. The aim of this study was to identify the frequency of vacA genotypes of H. pylori isolated from the upper gastrointestinal. Methods: One hundred H. pylori strains were isolated from patients with different gastrointestinal disease who admitted to Isfahan Al-zahra hospital. Vac A alleles were typed using PCR with specific primers. Findings: There were four Vac A mosaicsms, including 28 for s1a/m1 (28%), 23 for s1b/m1 (23%), 26 for s1a/m2 (26%) and 23 for s1b/m2 (23%), s2 form was not found. Conclusion: The results showed there is no significant relationship between different genotypes of vacA and the related diseases. © 2009, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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