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The Efficacy of Probiotics on Virus Titres and Antibody Production in Virus Diseases: A Systematic Review on Recent Evidence for Covid-19 Treatment Publisher Pubmed



Mirashrafi S1 ; Moravejolahkami AR1 ; Balouch Zehi Z2 ; Hojjati Kermani MA3 ; Bahreiniesfahani N4 ; Haratian M5 ; Ganjali Dashti M6 ; Pourhossein M4
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Nutrition, Vice Chancellor of Health, Hamadan University of Medical Sciences, Hamedan, Iran
  6. 6. Department of Biological Sciences, University of Texas at Dallas, 800 W Campbell Road, Richardson, TX, United States

Source: Clinical Nutrition ESPEN Published:2021


Abstract

Background & aims: There are some studies indicating the effects of probiotic-containing foods or supplements on viral diseases. We aimed to conduct a rapid review of probiotics with specific emphasis on their potential for early administration in patients at greater risk of SARS-CoV-2 infection. Methods: We searched on PubMed, EMBASE, Google Scholar, Science Direct, Scopus and Web of Science up to February 2021 to identify interventional and observational studies documenting the effects of probiotics strains on interleukins, virus titers, and antibody production with a focus on probiotic-containing foods (PROSPERO Registration ID. CRD42020181453) Results: From a total of 163 records, 21 studies were classified into three domains based on the efficacy of probiotics on 1) the level of interleukins (n = 7), 2) virus titers (n = 2), and 3) interferon (IFN) and antibody production (n = 12). The suppuration of pro-inflammatory interleukins and type I INF production seemed to be the main anti-viral effect of probiotics. Nine studies also indicated the beneficial effects of probiotics and fermented foods on viral diseases. Conclusion: Based on evidence, some probiotic strains may be useful in viral infections; randomized trials are needed to confirm these findings. © 2021 European Society for Clinical Nutrition and Metabolism
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