Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Assessment of Biochemical Factors in Blood Serum of Patients With Oral Squamous Cell Carcinoma Publisher



Keshani F1 ; Mahmoodi A2 ; Gholami M2 ; Azmoudeh F3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Pathology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Oral and Maxillofacial Pathology, Students Research Committee, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
  3. 3. Department of Oral and Maxillofacial Pathology, Dental Caries Prevention Research Center, Qazvin, Iran

Source: Dental Research Journal Published:2023


Abstract

Background: Recently, the role of biochemical factors in the etiology of oral squamous cell carcinoma (OSCC) has attracted some attention. Serum levels of biochemical factors may change in cancer patients. This study aimed to assess the serum level of folate, Vitamin B12, homocysteine, iron, copper, and selenium in patients with OSCC. Materials and Methods: This descriptive analytical study was conducted on 30 primary OSCC patients (15 males and 15 females) presenting to Imam Khomeini Cancer Institute, who had not yet undergone treatment. Blood samples were taken and serum levels of folate, Vitamin B12, homocysteine, iron, copper, and selenium were measured. Serum levels of micronutrients in patients with different tumor sizes were analyzed by one-way ANOVA. Serum levels of micronutrients were compared among groups with and without metastasis and lymph node involvement using Student's t-test (P < 0.05). Results: Serum levels of B12, folic acid, homocysteine, copper, iron, and selenium were 232.5 ± 102.68, 8.66 ± 4.06, 18.87 ± 8.81, 96.0 ± 22.64, 55.27 ± 40.58, and 92.47 ± 18.83 ng/mL, respectively. Relatively similar values were measured in patients with different tumor sizes with and without lymph node involvement and presence or absence distant metastasis. However, the serum level of folic acid in OSCC patients without lymph node involvement was significantly higher than that in OSCC patients with lymph node involvement (P < 0.05). Conclusion: Despite some variations, serum levels of micronutrients in OSCC patients were within the normal limits. Considering the variations in serum level of copper in OSCC patients, it may be used as a diagnostic marker. However, further studies are warranted in this respect. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.
Related Docs
View other Related Docs
1. The Comparative Study of Serum Iron, Copper, and Zinc Levels Between Bladder Cancer Patients and a Control Group, International Urology and Nephrology (2010)
2. Screening of Oral Squamous Cell Carcinoma by Serum Changes: A Systematic Review and Meta-Analysis, Dental Research Journal (2021)
3. Assessment of the Distribution of Usual Intake of Nutrients and Estimating Prevalence of Intake Deficiency and Excess in a General Over 40-Years of Age Population of Central Region of Iran: Application of the National Cancer Institute (Nci) Method, Journal of Isfahan Medical School (2013)
4. Vitamin D Intake, Serum Vitamin D Levels, and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2015)
5. Retinol and Α-Tocopherol Levels in the Serum and Subcutaneous Adipose Tissue of Newly Diagnosed Basal Cell Carcinoma Patients, Iranian Journal of Public Health (2019)
6. Patterns of Nutrient Intake in Relation to Gastric Cancer: A Case Control Study, Nutrition and Cancer (2022)
7. Dietary Intake of Antioxidants in the Elderly People Under Nursing Care: A Case-Control Study, International Journal of Preventive Medicine (2019)
8. Ultra-Processed Food Intake and Risk of Colorectal Cancer: A Matched Case-Control Study, Nutrition and Cancer (2023)
Experts (# of related papers)
View all Related Experts
Zahra Heidari (4)
Awat Feizi (4)
Other Related Docs
9. Effect of Vitamins C and E on Cancer Survival; a Systematic Review, DARU, Journal of Pharmaceutical Sciences (2022)
10. Assessment of the Quality of Life of the Patients With Treated Oral Cancer in Iran, Oral and Maxillofacial Surgery (2017)
11. Vitamin D and Bone Minerals Status in the Long‑Term Survivors of Childhood Acute Lymphoblastic Leukemia, International Journal of Preventive Medicine (2015)
12. Usual Intake Distribution of Vitamins and Prevalence of Inadequacy in a Large Sample of Iranian At-Risk Population: Application of Nci Method, Journal of the American College of Nutrition (2016)
13. Treatment of Chemotherapy Induced Anemia; a Randomized Clinical Trial to Compare Quality of Life in Patients Taking Intravenous Versus Oral Iron, Immunopathologia Persa (2021)
14. Bladder Cancer: Total Antioxidant Capacity and Pharmacotherapy With Vitamin-E, International Urology and Nephrology (2020)
15. The Effects of Vitamin E and Selenium on Cisplatininduced Nephrotoxicity in Cancer Patients Treated With Cisplatin-Based Chemotherapy: A Randomized, Placebo-Controlled Study, Journal of Research in Medical Sciences (2012)
16. Evaluation of Copper Salivary Level in Oral Squamous Cell Carcinoma, Occupationally Copper Exposed, and Its Normal Population and Its Association With Cytomorphologic Changes of Oral Mucosa, Dental Research Journal (2023)
17. Erythrocyte Membrane Saturated Fatty Acids Profile in Newly Diagnosed Basal Cell Carcinoma Patients, Clinical Nutrition ESPEN (2018)
18. Manganese, Chromium and the Oxidation Status in Bladder Cancer, Trace Elements and Electrolytes (2009)
19. The Association Between Circulating Carotenoids and Risk of Breast Cancer: A Systematic Review and Dose–Response Meta-Analysis of Prospective Studies, Advances in Nutrition (2024)
20. Adherence to the Low Carbohydrate Diet and the Risk of Breast Cancer in Iran, Nutrition Journal (2019)
21. The Association Between Vitamin D and Health Outcomes in Women: A Review on the Related Evidence, Journal of Research in Medical Sciences (2016)
22. Dietary Total Antioxidant Capacity and Risk of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis of Observational Studies, Archives of Iranian Medicine (2019)
23. Evaluation of the Cytotoxicity Effects of Ethanolic Extract of Ferula Assafoetida Resin on Oral Squamous Cells Carcinoma (Kb) Compared With L929 Cells, New Armenian Medical Journal (2023)
24. Minerals Intake Distributions in a Large Sample of Iranian At-Risk Population Using the National Cancer Institute Method: Do They Meet Their Requirements?, International Journal for Vitamin and Nutrition Research (2015)
25. The Study of the Serum Manganese Concentration in the Bladder Cancer Patients in Comparison With Healthy Subjects, Journal of Isfahan Medical School (2008)
26. Genetic Variations in Vdr Could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity Among Breast Cancer Women: A Randomized Double Blind Controlled Trial, Asian Pacific Journal of Cancer Prevention (2019)
27. Sugar Sweetened Beverages, Natural Fruit Juices, and Cancer: What We Know and What Still Needs to Be Assessed, Frontiers in Nutrition (2023)
28. Does Vitamin E Mitigate Cisplatin-Induced Nephrotoxicity in Cancer Patients: Results From a Randomized Placebo-Controlled Clinical Trial, Middle East Journal of Cancer (2020)
29. Oxidative Balance Score and Dietary Phytochemical Index Can Reduce the Risk of Colorectal Cancer in Iranian Population, BMC Gastroenterology (2023)
30. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Nutrition Reviews (2025)
31. Selenium Homeostasis and Clustering of Cardiovascular Risk Factors: A Systematic Review, Acta Biomedica (2017)
32. Changes in Salivary Antioxidants in Patients With Oral Squamous Cell Carcinoma: Systematic Review Study and Meta-Analysis, Journal of Advances in Medical and Biomedical Research (2022)
33. Evaluation of Metastasis and 5-Year Survival in Oral Squamous Cell Carcinoma Patients in Isfahan (2001-2015), Dental Research Journal (2019)
34. Association Between Dietary Intake of Fatty Acids and Colorectal Cancer, a Case-Control Study, Frontiers in Nutrition (2022)
35. Folic Acid Intake and Risk of Breast Cancer, Journal of Isfahan Medical School (2018)
36. Effects of Folate Supplementation on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2/3 in Overweight and Obese Women: A Randomized Double-Blind Placebo-Controlled Trial, European Journal of Clinical Nutrition (2022)
37. Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients, International Journal of Radiation Oncology Biology Physics (2015)
38. Serum Vitamins and Trace Elements in Vitiligo Patients: A Systematic Review and Meta-Analysis of Observational Studies, JEADV Clinical Practice (2024)
39. A Comparative Analysis of Dominant Dietary Patterns in Patients With and Without Oral Squamous Cell Carcinoma, Advanced Biomedical Research (2023)
40. Comparison of Serum Selenium Levels in Patients With Hodgkin’S Disease and Healthy People, Journal of Isfahan Medical School (2011)
41. A Case-Control Study on Dietary Calcium Intake and Risk of Glioma, European Journal of Cancer Prevention (2021)
42. The Effect of Mediterranean Diet on Nutritional Status, Muscle Mass and Strength, and Inflammatory Factors in Patients With Colorectal Cancer-Induced Cachexia: Study Protocol for a Randomized Clinical Trial, Trials (2022)
43. Effect of Vitamin E on Oxaliplatin-Induced Peripheral Neuropathy Prevention: A Randomized Controlled Trial, International Journal of Preventive Medicine (2015)
44. The Association Between Dietary Calcium Intake and Breast Cancer Risk Among Iranian Women, Nutrition and Cancer (2022)