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Insulin Receptor Substrate 2 Gene Gly1057asp Polymorphism Is a Risk Factor for Nonalcoholic Fatty Liver Disease Publisher Pubmed



Nouri S1 ; Mahmoudi T2 ; Hojjati F2 ; Najafabadi ZN3 ; Shafiee R4 ; Sayedsalehi S2 ; Dehghanitafti A2 ; Ardalani A2 ; Kohansal K5 ; Rezamand G6, 7 ; Asadi A8 ; Nobakht H9 ; Dabiri R9 ; Farahani H10 Show All Authors
Authors
  1. Nouri S1
  2. Mahmoudi T2
  3. Hojjati F2
  4. Najafabadi ZN3
  5. Shafiee R4
  6. Sayedsalehi S2
  7. Dehghanitafti A2
  8. Ardalani A2
  9. Kohansal K5
  10. Rezamand G6, 7
  11. Asadi A8
  12. Nobakht H9
  13. Dabiri R9
  14. Farahani H10
  15. Tabaeian SP6, 7
  16. Zali MR2
Show Affiliations
Authors Affiliations
  1. 1. Department of Radiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
  2. 2. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Clinical Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
  5. 5. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
  9. 9. Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran
  10. 10. Department of Physiology and Pharmacology, School of Medicine, Qom University of Medical Sciences, Qom, Iran

Source: Lab Medicine Published:2024


Abstract

Objective: Nonalcoholic fatty liver disease (NAFLD), which is an emerging global chronic liver disease, has a close association with insulin resistance. We aimed to determine whether the Gly1057Asp (rs1805097) polymorphism of the insulin receptor substrate 2 (IRS2) gene is associated with NAFLD. Methods: Using the polymerase chain reaction-restriction fragment length polymorphism method, 135 patients with biopsy-proven NAFLD and 135 controls underwent IRS2 genotype analysis. Results: Genotype and allele distributions of the IRS2 gene Gly1057Asp variant conformed to the Hardy-Weinberg equilibrium in both the case and control groups (P > .05). The Asp/Asp genotype of IRS2 gene Gly1057Asp polymorphism compared with Gly/Gly genotype was associated with a 2.1-fold increased risk for NAFLD after adjustment for confounding factors (P = .029; odds ratio = 2.10, 95% CI = 1.23-3.97). Conclusion: Our findings revealed for the first time that the Gly1057Asp Asp/Asp genotype of the IRS2 gene is a marker of increased NAFLD susceptibility; however, studies in other populations are required to confirm the results. © The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved.
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