Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces

Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces

Ramezani F¹ ; Alavian SM² ; Sadeghi A¹ ; Khedive A¹ ; Ghalichi L³ ; Norouzi M¹ ; Karimzadeh H¹ ; Malekzadeh R⁴ ; Montazeri G⁴ ; Nejatizadeh A⁵ ; Ziaee M⁶ ; Abedi F⁷ ; Ataei B⁸ ; Yaran M⁸ Show All Authors

Ramezani F¹
Alavian SM²
Sadeghi A¹
Khedive A¹
Ghalichi L³
Norouzi M¹
Karimzadeh H¹
Malekzadeh R⁴
Montazeri G⁴
Nejatizadeh A⁵
Ziaee M⁶
Abedi F⁷
Ataei B⁸
Yaran M⁸
Sayad B⁹
Somi MH¹⁰
Sarizadeh G¹¹
Saneimoghaddam I¹²
Mansourghanaei F¹³
Rafatpanah H¹⁴
Keyvani H¹⁵
Kalantari E¹⁶
Saberfiroozi M¹⁷
Rezaee R¹⁸
Daram M¹
Mahabadi M¹
Goodarzi Z¹
Poortahmasebi V¹
Geravand B¹⁸
Khamseh A¹
Mahmoodi M¹
Jazayeri SM¹

Show Affiliations

1. Hepatitis B Molecular Laboratory-Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. Middle East Liver Diseases Center (MELD Centers), Tehran, Iran
3. Mental health research center, Iran University of Medical Sciences, Tehran, Iran
4. Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Research Center for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
6. Hepatitis Research Center, Department of Internal Medicine, Birjand University of Medical Sciences, Birjand, Iran
7. Department of Infectious Disease, Mashhad University of Medical Sciences, Iran
8. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
9. Kermanshah Liver Diseases and Hepatitis Research Center, Kermanshah, Iran
10. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
11. Educational Region of Khozestan Blood Transfusion Organization, Ahvaz, Iran
12. Department of Gastroenterology, Zahedan University of Medical Sciences, Zahedan, Iran
13. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
14. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
15. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
16. Gholhack medical laboratory Tehran, Iran
17. Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
18. Ministry of Health and Medical Education, Deputy of Curative Affairs, Budget Administration, Tehran, Iran

Source: Iranian Journal of Microbiology Published:2015

Abstract

Background and Objectives: Iranian chronic HBV carrier’s population has shown a unique pattern of genotype D distribution all around the country. The aim of this study was to explore more details of evolutionary history of carriers based on structural surface proteins from different provinces. Materials and Methods: Sera obtained from 360 isolates from 12 Different regions of country were used for amplification and sequencing of surface proteins. A detailed mutational analysis was undertaken. Results: The total ratio for Missense/Silent nucleotide substitutions was 0.96. Sistan and Kermanshah showed the lowest rate of evolution between provinces (P = 0.055). On the other hand, Khorasan Razavi and Khoozestan contained the highest ratio (P = 0.055). The rest of regions were laid between these two extremes. Azarbayjan and Guilan showed the highest proportion of immune epitope distribution (91.3% and 96%, respectively). Conversely, Sistan and Tehran harbored the least percentage (66.6% and 68.8%, respectively). Kermanshah province contained only 5.2%, whereas Isfahan had 54.5% of B cell epitope distribution. In terms of T helper epitopes, all provinces showed a somehow homogeneity: 22.58% (Fars) to 46.6% (Khuzestan). On the other hand, distribution of substitutions within the CTL epitopes showed a wide range of variation between 6.6% (Khuzestan) and 63% (Kermanshah). Conclusion: Further to low selection pressure found in Iranian population, the variations between different regions designate random genetic drift within the surface proteins. These finding would have some applications in terms of specific antiviral regimen, design of more efficient vaccine and public health issues. © 2015, Tehran University of Medical Science. All rights reserved.

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Style	Citing Format
MLA	Ramezani F, et al.. "Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces." Iranian Journal of Microbiology, vol. 7, no. 4, 2015, pp. 214-220.
APA	Ramezani F, Alavian SM, Sadeghi A, Khedive A, Ghalichi L, Norouzi M, Karimzadeh H, Malekzadeh R, Montazeri G, Nejatizadeh A, Ziaee M, Abedi F, Ataei B, Yaran M, Sayad B, Somi MH, Sarizadeh G, Saneimoghaddam I, Mansourghanaei F, ... Jazayeri SM (2015). Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces. Iranian Journal of Microbiology, 7(4), 214-220.
Chicago	Ramezani F, Alavian SM, Sadeghi A, Khedive A, Ghalichi L, Norouzi M, Karimzadeh H, et al.. "Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces." Iranian Journal of Microbiology 7, no. 4 (2015): 214-220.
Harvard	Ramezani F et al. (2015) 'Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces', Iranian Journal of Microbiology, 7(4), pp. 214-220.
Vancouver	Ramezani F, Alavian SM, Sadeghi A, Khedive A, Ghalichi L, Norouzi M, et al.. Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces. Iranian Journal of Microbiology. 2015;7(4):214-220.
BibTex	@article{ author = {Ramezani F and Alavian SM and Sadeghi A and Khedive A and Ghalichi L and Norouzi M and Karimzadeh H and Malekzadeh R and Montazeri G and Nejatizadeh A and Ziaee M and Abedi F and Ataei B and Yaran M and Sayad B and Somi MH and Sarizadeh G and Saneimoghaddam I and Mansourghanaei F and Rafatpanah H and Keyvani H and Kalantari E and Saberfiroozi M and Rezaee R and Daram M and Mahabadi M and Goodarzi Z and Poortahmasebi V and Geravand B and Khamseh A and Mahmoodi M and Jazayeri SM}, title = {Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces}, journal = {Iranian Journal of Microbiology}, volume = {7}, number = {4}, pages = {214-220}, year = {2015} }
RIS	TY - JOUR AU - Ramezani F AU - Alavian SM AU - Sadeghi A AU - Khedive A AU - Ghalichi L AU - Norouzi M AU - Karimzadeh H AU - Malekzadeh R AU - Montazeri G AU - Nejatizadeh A AU - Ziaee M AU - Abedi F AU - Ataei B AU - Yaran M AU - Sayad B AU - Somi MH AU - Sarizadeh G AU - Saneimoghaddam I AU - Mansourghanaei F AU - Rafatpanah H AU - Keyvani H AU - Kalantari E AU - Saberfiroozi M AU - Rezaee R AU - Daram M AU - Mahabadi M AU - Goodarzi Z AU - Poortahmasebi V AU - Geravand B AU - Khamseh A AU - Mahmoodi M AU - Jazayeri SM TI - Evolution of Hepatitis B Virus Surface Gene and Protein Among Iranian Chronic Carriers From Different Provinces JO - Iranian Journal of Microbiology VL - 7 IS - 4 SP - 214 EP - 220 PY - 2015 ER -

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