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Cotton Fabric Incorporated With Β-Cyclodextrin/Ketoconazole/Ag Nps Generating Outstanding Antifungal and Antibacterial Performances Publisher



Hedayati N1 ; Montazer M1 ; Mahmoudirad M2 ; Toliyat T3
Authors
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Authors Affiliations
  1. 1. Textile Engineering Department, Functional Fibrous Structures and Environmental Enhancement (FFSEE), Amirkabir Nanotechnology Research Institute (ANTRI), Amirkabir University of Technology, Tehran, Iran
  2. 2. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellulose Published:2021


Abstract

Abstract: The influence of ketoconazole and β-CD/ketoconazole on cotton fabric as fungal skincare was previously reported however the impact of nanosilver on the antifungal and antibacterial properties of the same products is unknown. Here, silver NPs were synthesized on β-CD/KZ composite and then loaded on cotton fabric by using a cross-linking agent. The nanocomposite and treated fabrics were analyzed by diffenent means such as UV–vis, dynamic light scattering, zeta-potential and FE-SEM. The nanocomposite antimicrobial efficiency was examined on Candida albicans and Aspergillus niger as fungi and E. coli and S. aureus as bacteria. The synthesis of Ag NPs on β-CD/KZ amplifies both antifungal and antibacterial efficiencies. Having tremendous antimicrobial activities without cytotoxicity effects and drug release regularity with excellent washing durability makes the product suitable for medical applications as well as wound dressings and sportswear designed for sensitive skin. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Nature B.V.
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