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The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review Publisher Pubmed



Jafarizade M1 ; Kahe F2 ; Sharfaei S3 ; Momenzadeh K4 ; Pitliya A5 ; Zahedi Tajrishi F6 ; Singh P7 ; Chi G2
Authors
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Authors Affiliations
  1. 1. Lehigh Valley Health Network, Allentown, PA, United States
  2. 2. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
  3. 3. Baim Institute for Clinical Research, Boston, MA, United States
  4. 4. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
  5. 5. West Virginia University College of Medicine/Camden Clark Medical Center, Parkersburg, WV, United States
  6. 6. Tehran Heart Center, Tehran, Iran
  7. 7. Mass General Hospital, Harvard Medical School, Boston, MA, United States

Source: Cardiology (Switzerland) Published:2021


Abstract

Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor was also observed in the atherosclerotic plaques. In addition, circulatory IL-27 levels were increased in patients with acute coronary syndrome and myocardial infarction. A regenerative, neovascularization, and cardioprotective role of IL-27 has also been implicated. Future studies are warranted to elucidate the biologic function and clinical significance of IL-27 in atherosclerosis. © 2021
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