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Il-35, a Double-Edged Sword in Cancer Publisher Pubmed



Yazdani Z1 ; Rafiei A1 ; Golpour M2 ; Zafari P1, 2 ; Moonesi M3 ; Ghaffari S4, 5
Authors

Source: Journal of Cellular Biochemistry Published:2020


Abstract

Interleukin 35 (IL-35), a cytokine mainly produced by regulatory T cells (Treg cells), is composed of an Epstein-Barr virus–induced gene 3 β-chain and an IL-12 p35 α-chain. IL-35 causes tumorigenicity in cancer, protects cancer cells against apoptosis, and facilitates cancer progression. However, a few reports have referred to its contradictory roles in cancer prevention. Therefore, the exact purpose of this cytokine in cancer development has become a fundamental question that needs to be answered. In this review, we explain the structure of IL-35 and its receptors and their different signaling pathways. Finally, the function of IL-35 in some cancers and the possible application of this cytokine in approaches for cancer therapy have been discussed. © 2019 Wiley Periodicals, Inc.
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