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Il-35, a Double-Edged Sword in Cancer Publisher Pubmed



Yazdani Z1 ; Rafiei A1 ; Golpour M2 ; Zafari P1, 2 ; Moonesi M3 ; Ghaffari S4, 5
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Students Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Hematology, School of Medicine, Tabriz University of Medical Science, Tabriz, Iran
  4. 4. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular Biochemistry Published:2020


Abstract

Interleukin 35 (IL-35), a cytokine mainly produced by regulatory T cells (Treg cells), is composed of an Epstein-Barr virus–induced gene 3 β-chain and an IL-12 p35 α-chain. IL-35 causes tumorigenicity in cancer, protects cancer cells against apoptosis, and facilitates cancer progression. However, a few reports have referred to its contradictory roles in cancer prevention. Therefore, the exact purpose of this cytokine in cancer development has become a fundamental question that needs to be answered. In this review, we explain the structure of IL-35 and its receptors and their different signaling pathways. Finally, the function of IL-35 in some cancers and the possible application of this cytokine in approaches for cancer therapy have been discussed. © 2019 Wiley Periodicals, Inc.
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