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Approach to the Management of Autoimmunity in Primary Immunodeficiency Publisher Pubmed



Azizi G1, 2 ; Ziaee V3, 4 ; Tavakol M5 ; Alinia T2 ; Yazdai R2, 6 ; Mohammadi H7 ; Abolhassani H2, 8 ; Aghamohammadi A2
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Source: Scandinavian Journal of Immunology Published:2017


Abstract

Primary immunodeficiency diseases (PIDs) consist of a genetically heterogeneous group of immune disorders that affect distinct elements of the immune system. PID patients are more prone to infections and non-infectious complications, particularly autoimmunity. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and leads to difficulty in the management of autoimmune complications in PID patients. Therefore, management of autoimmunity in patients with PID requires special considerations because dysregulations and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment. © 2016 The Foundation for the Scandinavian Journal of Immunology
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