Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?

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Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency? Publisher Pubmed

Tak Manesh A¹ ; Azizi G^{2, 3} ; Heydari A³ ; Kiaee F³ ; Shaghaghi M³ ; Hosseinkhannazer N⁴ ; Yazdani R⁵ ; Abolhassani H^{3, 6} ; Aghamohammadi A³

Show Affiliations

1. Member of RACGP, Melbourne, Australia
2. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
6. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden

Source: Allergologia et Immunopathologia Published:2017

Abstract

Common variable immunodeficiency (CVID) is a diagnostic category of primary immunodeficiency (PID) which may present with heterogeneous disorders including recurrent infections, autoimmunity, granulomatous diseases, lymphoid and other types of malignancies. Generally, the incidence of malignancy in CVID patients is around 1.5–20.7% and usually occurs during the 4th–6th decade of life. Non-Hodgkin lymphoma is the most frequent malignancy, followed by epithelial tumours of stomach, breast, bladder and cervix. The exact pathological mechanisms for cancer development in CVID are not fully determined; however, several mechanisms including impaired genetic stability, genetic predisposition, immune dysregulation, impaired clearance of oncogenic viruses and bacterial infections, and iatrogenic causes have been proposed to contribute to the high susceptibility of these patients to malignancies. © 2017

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Style	Citing Format
MLA	Tak Manesh A, et al.. "Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?." Allergologia et Immunopathologia, vol. 45, no. 6, 2017, pp. 602-615.
APA	Tak Manesh A, Azizi G, Heydari A, Kiaee F, Shaghaghi M, Hosseinkhannazer N, Yazdani R, Abolhassani H, Aghamohammadi A (2017). Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?. Allergologia et Immunopathologia, 45(6), 602-615.
Chicago	Tak Manesh A, Azizi G, Heydari A, Kiaee F, Shaghaghi M, Hosseinkhannazer N, Yazdani R, Abolhassani H, Aghamohammadi A. "Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?." Allergologia et Immunopathologia 45, no. 6 (2017): 602-615.
Harvard	Tak Manesh A et al. (2017) 'Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?', Allergologia et Immunopathologia, 45(6), pp. 602-615.
Vancouver	Tak Manesh A, Azizi G, Heydari A, Kiaee F, Shaghaghi M, Hosseinkhannazer N, et al.. Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?. Allergologia et Immunopathologia. 2017;45(6):602-615.
BibTex	@article{ author = {Tak Manesh A and Azizi G and Heydari A and Kiaee F and Shaghaghi M and Hosseinkhannazer N and Yazdani R and Abolhassani H and Aghamohammadi A}, title = {Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?}, journal = {Allergologia et Immunopathologia}, volume = {45}, number = {6}, pages = {602-615}, year = {2017} }
RIS	TY - JOUR AU - Tak Manesh A AU - Azizi G AU - Heydari A AU - Kiaee F AU - Shaghaghi M AU - Hosseinkhannazer N AU - Yazdani R AU - Abolhassani H AU - Aghamohammadi A TI - Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency? JO - Allergologia et Immunopathologia VL - 45 IS - 6 SP - 602 EP - 615 PY - 2017 ER -

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