Autoimmunity in Common Variable Immunodeficiency: Epidemiology, Pathophysiology and Management Publisher Pubmed



Azizi G^{1, 2, 3} ; Abolhassani H^{2, 4} ; Asgardoon MH^{2, 5} ; Alinia T² ; Yazdani R⁶ ; Mohammadi J⁷ ; Rezaei N² ; Ochs HD⁸ ; Aghamohammadi A^{2, 3}
Source: Expert Review of Clinical Immunology Published:2017

Abstract

Introduction: Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency. Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infiltrates, malignancy, inflammatory and autoimmune conditions are also prevalent. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and creates difficulties in the management of autoimmune complications affecting these patients. Expert commentary: The management of autoimmunity in patients with CVID requires special considerations because dysregulation and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment. © 2016 Informa UK Limited, trading as Taylor & Francis Group.