Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis

Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis Publisher Pubmed

Emami Aleagha MS¹ ; Siroos B² ; Ahmadi M² ; Balood M¹ ; Palangi A¹ ; Haghighi AN² ; Harirchian MH²

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1. Department of Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2. Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Neuroimmunology Published:2015

Abstract

Recent investigations support that an anti-aging protein, namely Klotho, protects neurons against the oxidative stress and demyelination. We evaluated the protein concentration of Klotho and total anti-oxidant capacity (TAC) in the cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RRMS). Klotho concentration and TAC were significantly lower in patients as compared to controls. Klotho values showed a significant negative correlation with expanded disability status scale (EDSS). Moreover, a significantly positive correlation between TAC levels and Klotho concentrations was detected. Klotho may play an important role in the pathogenesis of MS, at least in part, through the regulation of redox system. © 2015 Elsevier B.V.

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Mohammad Ali Sahraian (3)

Mohammad Hossein Harirchian (3)

Style	Citing Format
MLA	Emami Aleagha MS, et al.. "Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis." Journal of Neuroimmunology, vol. 281, no. , 2015, pp. 5-8.
APA	Emami Aleagha MS, Siroos B, Ahmadi M, Balood M, Palangi A, Haghighi AN, Harirchian MH (2015). Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis. Journal of Neuroimmunology, 281(), 5-8.
Chicago	Emami Aleagha MS, Siroos B, Ahmadi M, Balood M, Palangi A, Haghighi AN, Harirchian MH. "Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis." Journal of Neuroimmunology 281, no. (2015): 5-8.
Harvard	Emami Aleagha MS et al. (2015) 'Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis', Journal of Neuroimmunology, 281(), pp. 5-8.
Vancouver	Emami Aleagha MS, Siroos B, Ahmadi M, Balood M, Palangi A, Haghighi AN, et al.. Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis. Journal of Neuroimmunology. 2015;281():5-8.
BibTex	@article{ author = {Emami Aleagha MS and Siroos B and Ahmadi M and Balood M and Palangi A and Haghighi AN and Harirchian MH}, title = {Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis}, journal = {Journal of Neuroimmunology}, volume = {281}, number = {}, pages = {5-8}, year = {2015} }
RIS	TY - JOUR AU - Emami Aleagha MS AU - Siroos B AU - Ahmadi M AU - Balood M AU - Palangi A AU - Haghighi AN AU - Harirchian MH TI - Decreased Concentration of Klotho in the Cerebrospinal Fluid of Patients With Relapsing-Remitting Multiple Sclerosis JO - Journal of Neuroimmunology VL - 281 IS - SP - 5 EP - 8 PY - 2015 ER -

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