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Neurological Manifestations and Their Correlated Factors in Covid-19 Patients; a Cross-Sectional Study Publisher



Ashrafi F1 ; Ommi D1 ; Zali A1 ; Khani S2 ; Soheili A2 ; Arabahmadi M3 ; Behnam B4 ; Nohesara S5 ; Semnani F6 ; Fatemi A7 ; Salari M1 ; Khoshnood RJ1 ; Vahidi M2 ; Ayoobiyazdi N3 Show All Authors
Authors
  1. Ashrafi F1
  2. Ommi D1
  3. Zali A1
  4. Khani S2
  5. Soheili A2
  6. Arabahmadi M3
  7. Behnam B4
  8. Nohesara S5
  9. Semnani F6
  10. Fatemi A7
  11. Salari M1
  12. Khoshnood RJ1
  13. Vahidi M2
  14. Ayoobiyazdi N3
  15. Toudeshki SH8
  16. Sobhrakhshankhah E4
Show Affiliations
Authors Affiliations
  1. 1. Functional Neurosurgery Research Center, Shohadaye Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Infectious Diseases, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Radiation Oncology, Iran University of Medical Sciences, Tehran, Iran

Source: Archives of Academic Emergency Medicine Published:2021


Abstract

Introduction: COVID-19 might present with other seemingly unrelated manifestations; for instance, neuro-logical symptoms. This study aimed to evaluate the neurologic manifestations and their correlated factors in COVID-19 patients. Methods: This retrospective observational study was conducted from March 17, 2020 to June 20, 2020 in a tertiary hospital in Iran. The study population consisted of adult patients with a positive result for COVID-19 real-time reverse transcriptase polymerase chain reaction (RT-PCR) using nasopharyngeal swabs. Both written and electronic data regarding baseline characteristic, laboratory findings, and neurological mani-festations were evaluated and reported. Results: 727 COVID-19 patients with the mean age of 49.94 ± 17.49 years were studied (56.9% male). At least one neurological symptom was observed in 403 (55.4%) cases. Headache (29.0%), and smell (22.3%) and taste (22.0%) impairment were the most prevalent neurological symptoms, while seizure (1.1%) and stroke (2.3%) were the least common ones. Patients with neurological manifestations were significantly older (p = 0.04), had greater body mass index (BMI) (p = 0.02), longer first symptom to admission duration (p<0.001) and were more frequently opium users (p = 0.03) compared to COVID-19 patients without neurological symptoms. O2 saturation was significantly lower in patients with neurological manifestations (p = 0.04). In addition, medians of neutrophil count (p = 0.006), neutrophil-lymphocyte ratio (NLR) (p = 0.02) and c-reactive protein (CRP) (p = 0.001) were significantly higher and the median of lymphocyte count (p = 0.03) was significantly lower in patients with neurological manifestations. Conclusion: The prevalence of neurological manifestations in the studied cases was high (55.4%). This prevalence was significantly higher in older age, grated BMI, longer lasting disease, and opium usage. © 2021
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