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Interaction Between Harmane, a Class of Β-Carboline Alkaloids, and the Ca1 Serotonergic System in Modulation of Memory Acquisition Publisher Pubmed



Nasehi M1 ; Ghadimi F2 ; Khakpai F1 ; Zarrindast MR1, 3, 4, 5, 6, 7
Authors
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Authors Affiliations
  1. 1. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Biology, Faculty of Basic Sciences, Kharazmi (TarbiatMoalem) University, Tehran, Iran
  3. 3. Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  4. 4. Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
  7. 7. University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

Source: Neuroscience Research Published:2017


Abstract

This study set to assess the involvement of dorsal hippocampus (CA1) serotonergic system on harmane induced memory acquisition deficit. We used one trial step-down inhibitory avoidancetask to evaluate memory retention and then, open field test to evaluate locomotor activity in adult male NMRI mice. The results showed that pre-training intra-peritoneal (i.p.) administration of harmane (12 mg/kg) induced impairment of memory acquisition. Pre-training intra-CA1 administration of 5-HT1B/1D receptor agonist (CP94253; 0.5 and 5 ng/mouse) and 5-HT2A/2B/2C receptor agonist (α-methyl 5-HT; 50 ng/mouse) impaired memory acquisition. Furthermore, intra-CA1 administration of 5-HT1B/1D receptor antagonist (GR127935; 0.5 ng/mouse) and 5-HT2 receptor antagonist (cinancerine; 5 ng/mouse) improved memory acquisition. In addition, pre-training intra-CA1 injection of sub-threshold dose of CP94253 (0.05 ng/mouse) and α-methyl 5-HT (5 ng/mouse) potentiated impairment of memory acquisition induced by harmane (12 mg/kg, i.p.). On the other hand, pre-training intra-CA1 infusion of sub-threshold dose of GR127935 (0.05 ng/mouse) and cinancerine (0.5 ng/mouse) with the administration of harmane (12 mg/kg, i.p.) weakened impairment of memory acquisition. Moreover, all above doses of drugs did not change locomotor activity. The present findings suggest that there is an interaction between harmane and the CA1 serotonergic system in modulation of memory acquisition. © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society
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