Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations

Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations Publisher Pubmed

Liu JZ¹ ; Van Sommeren S^{2, 3} ; Huang H⁴ ; Ng SC⁵ ; Alberts R² ; Takahashi A⁶ ; Ripke S⁴ ; Lee JC⁷ ; Jostins L⁸ ; Shah T¹ ; Abedian S⁹ ; Cheon JH¹⁰ ; Cho J¹¹ ; Daryani NE¹² Show All Authors

Liu JZ¹
Van Sommeren S^{2, 3}
Huang H⁴
Ng SC⁵
Alberts R²
Takahashi A⁶
Ripke S⁴
Lee JC⁷
Jostins L⁸
Shah T¹
Abedian S⁹
Cheon JH¹⁰
Cho J¹¹
Daryani NE¹²
Franke L³
Fuyuno Y¹³
Hart A¹⁴
Juyal RC¹⁵
Juyal G¹⁶
Kim WH¹⁰
Morris AP¹⁷
Poustchi H⁹
Newman WG¹⁸
Midha V¹⁹
Orchard TR²⁰
Vahedi H⁹
Sood A¹⁹
Sung JJY⁵
Malekzadeh R⁹
Westra HJ³
Yamazaki K¹³
Yang SK²¹
Barrett JC¹
Franke A²²
Alizadeh BZ²³
Parkes M⁷
Thelma BK¹⁶
Daly MJ⁴
Kubo M¹³
Anderson CA¹
Weersma RK²

Source: Nature Genetics Published:2015

Abstract

Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of the IBD risk loci, the direction and magnitude of effect are consistent in European and non-European cohorts. Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture across diverse populations. © 2015 Nature America, Inc. All rights reserved.

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Nima Rezaei (6)

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Style	Citing Format
MLA	Liu JZ, et al.. "Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations." Nature Genetics, vol. 47, no. 9, 2015, pp. 979-986.
APA	Liu JZ, Van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Daryani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, ... Weersma RK (2015). Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations. Nature Genetics, 47(9), 979-986.
Chicago	Liu JZ, Van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, et al.. "Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations." Nature Genetics 47, no. 9 (2015): 979-986.
Harvard	Liu JZ et al. (2015) 'Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations', Nature Genetics, 47(9), pp. 979-986.
Vancouver	Liu JZ, Van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, et al.. Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations. Nature Genetics. 2015;47(9):979-986.
BibTex	@article{ author = {Liu JZ and Van Sommeren S and Huang H and Ng SC and Alberts R and Takahashi A and Ripke S and Lee JC and Jostins L and Shah T and Abedian S and Cheon JH and Cho J and Daryani NE and Franke L and Fuyuno Y and Hart A and Juyal RC and Juyal G and Kim WH and Morris AP and Poustchi H and Newman WG and Midha V and Orchard TR and Vahedi H and Sood A and Sung JJY and Malekzadeh R and Westra HJ and Yamazaki K and Yang SK and Barrett JC and Franke A and Alizadeh BZ and Parkes M and Thelma BK and Daly MJ and Kubo M and Anderson CA and Weersma RK}, title = {Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations}, journal = {Nature Genetics}, volume = {47}, number = {9}, pages = {979-986}, year = {2015} }
RIS	TY - JOUR AU - Liu JZ AU - Van Sommeren S AU - Huang H AU - Ng SC AU - Alberts R AU - Takahashi A AU - Ripke S AU - Lee JC AU - Jostins L AU - Shah T AU - Abedian S AU - Cheon JH AU - Cho J AU - Daryani NE AU - Franke L AU - Fuyuno Y AU - Hart A AU - Juyal RC AU - Juyal G AU - Kim WH AU - Morris AP AU - Poustchi H AU - Newman WG AU - Midha V AU - Orchard TR AU - Vahedi H AU - Sood A AU - Sung JJY AU - Malekzadeh R AU - Westra HJ AU - Yamazaki K AU - Yang SK AU - Barrett JC AU - Franke A AU - Alizadeh BZ AU - Parkes M AU - Thelma BK AU - Daly MJ AU - Kubo M AU - Anderson CA AU - Weersma RK TI - Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations JO - Nature Genetics VL - 47 IS - 9 SP - 979 EP - 986 PY - 2015 ER -

Style

Citing Format

MLA

Liu JZ, et al.. "Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations." Nature Genetics, vol. 47, no. 9, 2015, pp. 979-986.

APA

Liu JZ, Van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Daryani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, ... Weersma RK (2015). Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations. Nature Genetics, 47(9), 979-986.

Chicago

Liu JZ, Van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, et al.. "Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations." Nature Genetics 47, no. 9 (2015): 979-986.

Harvard

Liu JZ et al. (2015) 'Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations', Nature Genetics, 47(9), pp. 979-986.

Vancouver

Liu JZ, Van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, et al.. Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations. Nature Genetics. 2015;47(9):979-986.

BibTex

@article{ author = {Liu JZ and Van Sommeren S and Huang H and Ng SC and Alberts R and Takahashi A and Ripke S and Lee JC and Jostins L and Shah T and Abedian S and Cheon JH and Cho J and Daryani NE and Franke L and Fuyuno Y and Hart A and Juyal RC and Juyal G and Kim WH and Morris AP and Poustchi H and Newman WG and Midha V and Orchard TR and Vahedi H and Sood A and Sung JJY and Malekzadeh R and Westra HJ and Yamazaki K and Yang SK and Barrett JC and Franke A and Alizadeh BZ and Parkes M and Thelma BK and Daly MJ and Kubo M and Anderson CA and Weersma RK}, title = {Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations}, journal = {Nature Genetics}, volume = {47}, number = {9}, pages = {979-986}, year = {2015} }

RIS

TY - JOUR
AU - Liu JZ
AU - Van Sommeren S
AU - Huang H
AU - Ng SC
AU - Alberts R
AU - Takahashi A
AU - Ripke S
AU - Lee JC
AU - Jostins L
AU - Shah T
AU - Abedian S
AU - Cheon JH
AU - Cho J
AU - Daryani NE
AU - Franke L
AU - Fuyuno Y
AU - Hart A
AU - Juyal RC
AU - Juyal G
AU - Kim WH
AU - Morris AP
AU - Poustchi H
AU - Newman WG
AU - Midha V
AU - Orchard TR
AU - Vahedi H
AU - Sood A
AU - Sung JJY
AU - Malekzadeh R
AU - Westra HJ
AU - Yamazaki K
AU - Yang SK
AU - Barrett JC
AU - Franke A
AU - Alizadeh BZ
AU - Parkes M
AU - Thelma BK
AU - Daly MJ
AU - Kubo M
AU - Anderson CA
AU - Weersma RK
TI - Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk Across Populations
JO - Nature Genetics
VL - 47
IS - 9
SP - 979
EP - 986
PY - 2015
ER -

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Authors

Abstract