Autologous Platelet-Rich Plasma Infusion Does Not Improve Pregnancy Outcomes in Frozen Embryo Transfer Cycles in Women With History of Repeated Implantation Failure Without Thin Endometrium Publisher Pubmed



Tehraninejad ES¹ ; Kashani NG¹ ; Hosseini A¹ ; Tarafdari A¹ Show Affiliations
Source: Journal of Obstetrics and Gynaecology Research Published:2021

Abstract

Aim: The effect of intrauterine infusion of platelet-rich plasma (PRP) which has been shown to improve the pregnancy outcomes in patients suffering from repeated implantation failure (RIF), is intended to be studied in patients with normal endometrial thickness. Methods: We recruited 85 patients with RIF and normal endometrial thickness (≥7 mm). After obtaining their consent, they were stratified into the intervention (PRP) and control groups, according to the patient's decision. Out of 85 participants, 42 received PRP, while 43 were included in the control group. In the PRP group, 1 mL of PRP was extracted from 10 cc of whole blood via two rounds of centrifugation and infused 2 days before the embryo transfer (ET). Results: The pregnancy outcomes, including biochemical, clinical and ongoing pregnancy (≥20 weeks of gestation) rates were similar between the PRP (35.7, 31.0 and 26.8%, respectively) and control (37.2, 37.2 and 25.6%, respectively) groups. Conclusion: We concluded that PRP is not an effective adjuvant treatment for in vitro fertilization of patients with RIF and normal endometrial thickness undergoing ET. © 2020 Japan Society of Obstetrics and Gynecology