Mesoporous Silica Coated Spions Containing Curcumin and Silymarin Intended for Breast Cancer Therapy Publisher Pubmed



Sadegha S¹ ; Varshochian R^{2, 3} ; Dadras P⁴ ; Hosseinzadeh H¹ ; Sakhtianchi R¹ ; Mirzaie ZH² ; Shafiee A¹ ; Atyabi F^{1, 2} ; Dinarvand R^{1, 2} Show Affiliations
Source: DARU# Journal of Pharmaceutical Sciences Published:2022

Abstract

Introduction: Super-paramagnetic iron oxide nanoparticles (SPIONs) are known as promising theranostic nano-drug carriers with magnetic resonance imaging (MRI) properties. Applying the herbaceous components with cytotoxic effects as cargos can suggest a new approach in the field of cancer-therapy. In this study mesoporous silica coated SPIONs (mSiO2@SPIONs) containing curcumin (CUR) and silymarin (SIL) were prepared and evaluated on breast cancer cell line, MCF-7. Methods: Nanoparticles (NPs) were formulated by reverse microemulsion method and characterized by DLS, SEM and VSM. The in vitro drug release, cellular cytotoxicity, and MRI properties of NPs were determined as well. The cellular uptake of NPs by MCF-7 cells was investigated through LysoTracker Red staining using confocal microscopy. Results: The MTT results showed that the IC50 of CUR + SIL loaded mSiO2@SPIONs was reduced about 50% in comparison with that of the free drug mixture. The NPs indicated proper MRI features and cellular uptake through endocytosis. Conclusion: In conclusion the prepared formulation may offer a novel theranostic system for breast cancer researches. Graphical abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to Tehran University of Medical Sciences.