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Covid-19 in Transplant Recipient Children: An Iranian Referral Hospital-Based Study Publisher Pubmed



Mamishi S1 ; Ghazizadeh Esslami G4 ; Mahmoudi S5 ; Navaeian A5 ; Behfar M5 ; Hamidieh AA5 ; Alimadadi H5 ; Mahmoudieh Y6
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Authors Affiliations
  1. 1. a:1:{s:5:en_US
  2. 2. s:37:Tehran University of Medical sciences
  3. 3. }
  4. 4. Tehran University of Medical Sciences.
  5. 5. Tehran University of Medical Sciences
  6. 6. 7- Department of Molecular and Cell Biology, University of California, Berkeley

Source: Acta bio-medica : Atenei Parmensis Published:2021


Abstract

To our knowledge, there is still very limited information on the severity, mortality, laboratory, and radiologic findings of COVID-19 infection in transplant patients, particularly children. In this study, we report and analyze 7 transplant recipients with laboratory-confirmed COVID-19 infection. The median age was 7.5 years (IQR: 31month-10 years), and 71% of the patients were male. All cases presented with a fever. The median duration of fever before admission was 2 days (IQR:1-8 days). Five patients (71%) experienced cough and dyspnea. Lymphocytopenia (Median of 0.6 (IQR: 0.14-2.0× 10⁹ cells per L) and thrombocytopenia (Median of 65 (IQR: 49-201× 10⁹ cells per L) were the most common CBC findings (both seen in 5 out of the 7 patients. Among 4 of the patients who underwent CT scans, 2 had ground glass opacity and consolidations. The mean number of lobe involvement in our patients was 3(0-5), and 75% of the cases showed bilateral lung involvement in the imaging. In 4 patients (51%) the disease course manifested severely, and 2 patients are now deceased (28.6%). In conclusion, immunocompromised pediatric subgroups may experience higher rates of disease severity and mortality in comparison with the immunocompetent pediatric population.