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Determination of the Dose Enhancement Exclusively in Tumor Tissue Due to the Presence of Gnps Publisher Pubmed



Khodadadi A1 ; Nedaie HA2, 3 ; Sadeghi M4 ; Ghassemi MR5 ; Mesbahi A6 ; Banaee N7
Authors
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Authors Affiliations
  1. 1. Department of Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Radiation Oncology Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran university of medical sciences, Tehran, Iran
  4. 4. Medical Physics Department, School of Medicine, Iran University of Medical Science, Tehran, Iran
  5. 5. Accelerators Research, NSTRI, Karaj, Iran
  6. 6. Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Medical Radiation, Engineering Faculty, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Source: Applied Radiation and Isotopes Published:2019


Abstract

Purpose: The purpose of this study is to investigate the differences between obtained percentage dose enhancements in areas around nanoparticles in GNPs (gold nanoparticles) enriched medium and percentage dose enhancements in the entire GNPs enriched medium including nanoparticles region. Methods and materials: To verify the accuracy of Ir-192 source simulation, the obtained values of air kerma strength, dose rate constants, and radial dose functions were compared against previously published results. Then a 1 cm × 1 cm× 1 cm tumor volume loaded with different diameters of GNPs were considered at a source to the tumor center of 1 cm. Finally, dose enhancements were obtained for 50, 100 and 200 nm GNPs as a function of various concentrations of the radiosensitizer and depth in phantom. Results: Calculations showed that dose enhancement could be customized by varying the size of nanoparticles, concentrations and radial distance from the source. The highest PDE GNP (The ratio of the increased deposited dose in the tumor region to the dose deposition in the no nano gold-containing structure) was acquired by 50 nm nanoparticles, 30 mg/g concentrations and in the highest distance from the source. (PDE GNP ) and (PDE around−GNP ) due to the presence of 7–30 mg/g concentration of GNPs ranged from 3−18.19% and 3.45–21.13%, respectively. The results of this study revealed that the correlation is significant at the 0.01 level and there is a non-negligible difference (up to 3%) between (D around−GNP )and (D GNP ). Conclusion: By considering exclusively determination of dose enhancement in the just tumor tissue, calculating (D around−GNP ) Instead of D GNP may be a strategy for clinical use of nanoparticles in the radiation therapy. The results showed that with the increasing trend of dose enhancement in the GNPs loaded-tumor, dose enhancement decreases with an increase in the size of GNPs. © 2018 Elsevier Ltd
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