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An Overview of Biomedical Applications for Gold Nanoparticles Against Lung Cancer Publisher



Kumari V1 ; Vishwas S1 ; Kumar R1 ; Kakoty V1 ; Khursheed R1 ; Babu MR1 ; Harish V1 ; Mittal N2 ; Singh PK3 ; Alharthi NS4 ; Hakami MA5 ; Aba Alkhayl FF6 ; Gupta G7, 8 ; Rubis GD9, 10 Show All Authors
Authors
  1. Kumari V1
  2. Vishwas S1
  3. Kumar R1
  4. Kakoty V1
  5. Khursheed R1
  6. Babu MR1
  7. Harish V1
  8. Mittal N2
  9. Singh PK3
  10. Alharthi NS4
  11. Hakami MA5
  12. Aba Alkhayl FF6
  13. Gupta G7, 8
  14. Rubis GD9, 10
  15. Paudel KR11
  16. Singh M9, 10, 12
  17. Zandi M13
  18. Oliver BG14, 15
  19. Dua K9, 10, 16
  20. Singh SK1, 10
Show Affiliations
Authors Affiliations
  1. 1. School of Pharmaceutical Sciences, Lovely Professional University, Punjab, Phagwara, India
  2. 2. Chitkara College of Pharmacy, Chitkara University, Punjab, India
  3. 3. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India
  4. 4. Department of Medical Laboratory Sciences. College of Applied Medical Sciences in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  5. 5. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Al- Quwayiyah, Riyadh, Saudi Arabia
  6. 6. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia
  7. 7. School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  8. 8. Center for Transdisciplinary Research, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India
  9. 9. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, 2007, NSW, Australia
  10. 10. Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, 2007, NSW, Australia
  11. 11. Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, 2050, NSW, Australia
  12. 12. Department of Biotechnology, Jaypee Institute of Information Technology (JIIT), Sector - 62, Uttar Pradesh, Noida, India
  13. 13. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  14. 14. School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia
  15. 15. Woolcock Institute of Medical Research, Macquarie University, Sydney, 2137, NSW, Australia
  16. 16. Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

Lung cancer (LC) is the commonest class of cancer worldwide and is the reason for more deaths than any other type. Treatment of LC using conventional therapy has some limitations such as poor bioavailability and non-site release of drug causing various side effects. However, the use of nanotechnology makes it possible to offer efficacious treatment of LC by offering nanometer sized formulation that helps in better penetration of drug inside tumor cells and site specific drug release. Among various nanoparticles, gold nanoparticles (GNPs) has found unique and important application in the biomedical application of nanoparticles in various diseases, especially cancer. Owing to their high biocompatibility and stability against oxidation in vivo, tunable nano size, ease of functionalization with chemotherapeutic agents, capacity to enhance bioavailability and site specificity of entrapped drug, capacity to interact with visible light, make GNPs as special carrier for biomedical application in LC. GNPs can absorb infrared radiation and have optical qualities as well. In the present review, various aspects of LC and theranostic role of GNPs are comprehensively covered. These include prevalence, classification, economic burden, pathophysiology as well as commonly available therapies of LC. This was followed by advantages, synthesis, biomedical application of GNPs in treating LC as well as their fate in the body. Overall, the uniqueness of review relies on the fact that it covers all aspects of LC and all possibilities by which GNPs can offer their best role in management of LC. © 2023 Elsevier B.V.