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Monte Carlo Simulation and Analytical Calculation Methods to Investigate the Potential of Nanoparticles for Intrabeam® Iort Machine Publisher Pubmed



Omyan G1, 2 ; Gholami S2, 3 ; Zad AG1 ; Severgnini M4 ; Longo F5 ; Kalantari F6
Authors
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Authors Affiliations
  1. 1. Department of Physics, Faculty of Sciences, University of Guilan, Rasht, Iran
  2. 2. Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. The Abdus Salam International Centre for Theoretical Physics, Trieste, Italy
  4. 4. Medical Physics Department, Riuniti Hospital ASUITS, Trieste, Italy
  5. 5. Physics Department, University of Trieste and INFN sezione di Trieste, Trieste, Italy
  6. 6. Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, United States

Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2020


Abstract

In the present study, Monte Carlo (MC) simulation and analytical calculation methods were used to investigate the potential of cancer treatment for the combination of IORT with nanoparticles (NPs). The Geant4 MC toolkit was used to simulate ZEISS INTRABEAM® IORT machine and its smallest applicator with 1.5 cm diameter. The dose enhancement effects (DEFs) were obtained for silver (Ag), gold (Au), bismuth (Bi), copper (Cu) and iron (Fe) spherical NPs considering different concentrations. In addition, analytical calculations were performed based on attenuation coefficient formula for sample NPs. Our MC results showed that the use of different NPs led to an increase in DEF up to 40%. Among different NPs, Au had the maximum DEF. In addition, analytical calculations revealed a significant increase, using NPs as well. Our study has suggested that the use of NPs in combination with IORT has the potential to enhance treatment outcomes. © 2020 Elsevier Inc.
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