Conventional Mri-Derived Subchondral Trabecular Biomarkers and Their Association With Knee Cartilage Volume Loss As Early As 1 Year: A Longitudinal Analysis From Osteoarthritis Initiative Publisher Pubmed



Pishgar F¹ ; Ashrafganjouei A² ; Dolatshahi M³ ; Guermazi A⁴ ; Zikria B⁵ ; Cao X⁵ ; Wan M⁵ ; Roemer FW^{4, 6} ; Dam E⁷ ; Demehri S¹
Source: Skeletal Radiology Published:2022

Abstract

Objective: To study associations between MRI-derived subchondral trabecular biomarkers obtained from conventional MRI sequences and knee cartilage loss over 12 and 24 months, using the FNIH osteoarthritis (OA) biomarkers consortium. Materials and methods: Data of the 600 subjects in the FNIH OA biomarkers consortium (a nested case–control study within Osteoarthritis Initiative [OAI]) were extracted from the online database. Baseline knee MRI (intermediate-weighted (IW) sequences) were evaluated to determine conventional MRI-derived trabecular thickness (cTbTh) and bone-to-total ratio (cBV/TV). The measurements for medial and lateral volumes of cartilages using baseline, 12-, and 24-month knee MRI were extracted from the OAI database, and cartilage volume loss over 12 and 24 months of follow-up were determined using Relative Change Index. The association between conventional MRI-based subchondral trabecular biomarkers and cartilage volume loss were studied using logistic regression models, adjusted for relevant confounders including age, sex, body mass index (BMI), vitamin D use, Kellgren Lawrence grade (KLG), and tibiofemoral alignment. Results: Higher medial cTbTh and cBV/TV at baseline were associated with increased odds of medial tibial cartilage volume loss over 12 months (ORs: 1.01 [1.00–1.02] and 1.24 [1.10–1.39] per 1-SD change) and 24 months (ORs: 1.01 [1.00–1.02] and 1.22 [1.08–1.37], per 1-SD change). No significant association was observed between medial subchondral trabecular biomarkers and lateral tibial or femoral (medial or lateral) cartilage volume loss over the first and second follow-up years. Conclusions: Conventional MRI-derived subchondral trabecular biomarkers (higher medial cTbTh and cBV/TV) may be associated with increased medial tibial cartilage volume loss as early as 1 year. © 2022, The Author(s), under exclusive licence to International Skeletal Society (ISS).