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A Mechanistic Review on Plant-Derived Natural Compounds As Dietary Supplements for Prevention of Inflammatory Bowel Disease Publisher Pubmed



Farzaei MH1, 2 ; Bahramsoltani R3 ; Abdolghaffari AH4, 5, 11 ; Sodagari HR6 ; Esfahani SA7 ; Rezaei N8, 9, 10
Authors

Source: Expert Review of Gastroenterology and Hepatology Published:2016


Abstract

ABSTRACT: Inflammatory bowel disease (IBD) is a recurrent idiopathic inflammatory condition, characterized by disruption of the gut mucosal barrier. This mechanistic review aims to highlight the significance of plant-derived natural compounds as dietary supplements, which can be used in addition to restricted conventional options for the prevention of IBD and induction of remission. Various clinical trials confirmed the effectiveness and tolerability of natural supplements in patients with IBD. Mounting evidence suggests that these natural compounds perform their protective and therapeutic effect on IBD through numerous molecular mechanisms, including anti-inflammatory and immunoregulatory, anti-oxidative stress, modulation of intracellular signaling transduction pathways, as well as improving gut microbiota. In conclusion, natural products can be considered as dietary supplements with therapeutic potential for IBD, provided that their safety and efficacy is confirmed in future well-designed clinical trials with adequate sample size. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
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