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Development of Lanthanide-Based “All in One” Theranostic Nanoplatforms for Tme-Reinforced T1-Weighted Mri/Ct Bimodal Imaging Publisher



Sabaghi V1 ; Rashidiranjbar P1 ; Davar F2 ; Sharifpaghaleh E3, 4
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Department of Chemistry, Isfahan University of Technology, Isfahan, Iran
  3. 3. Department of Imaging Chemistry and Biology, Faculty of Life Sciences and Medicine, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

The design and development of lanthanide-based theranostic nanoplatforms, owing to unique physiochemical properties have attracted significant interest in enhancing the diagnostic and therapeutic efficiency against cancer. In this study, hollow Nd-doped Gd2O3 (H-NdxGd2-xO3) nanostructures were synthesized through the scarified template strategy. Qualitative and quantitative X-ray analysis confirmed the substitution of Nd3+ ions by Gd3+ ions in the cubic structure of pristine H–Gd2O3 nanostructure. Polyethylene glycol (PEG) successfully decorated the surface of the as-synthesized nanostructure to reduce the inherent toxicity. H-NdxGd2-xO3@PEG nanoplatforms showed a significant DOX adsorption capacity (149.5 mg/g). Biocompatible H-NdxGd2-xO3@PEG nanoplatforms showed a considerable response to the simulated tumor microenvironment (TME) of cancer. The characteristic features of simulated TME of cancer not only enhance the drug release efficiency (72%), but also reinforced the T1-weighted MRI signal (19.33 mM−1. S−1), and CT signal (247 HU). © 2023 Elsevier B.V.
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