Role of Green Tea Catechins in Prevention of Age-Related Cognitive Decline: Pharmacological Targets and Clinical Perspective Publisher Pubmed



Farzaei MH^{1, 2} ; Bahramsoltani R³ ; Abbasabadi Z⁴ ; Braidy N⁵ ; Nabavi SM⁶ Show Affiliations
Source: Journal of Cellular Physiology Published:2019

Abstract

Over the past decade, a wide range of scientific investigations have been performed to reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic approaches currently exist. The failures of conventional therapeutic options as well as the predicted dramatic rise in the prevalence of cognitive decline in the coming future show the necessity for novel therapeutic agents. Recently, a wide range of research has focused on pharmacological activities of green tea catechins worldwide. Current investigations have clarified mechanistic effects of the catechins in inflammatory cascades, oxidative damages, different cellular transcription as well as transduction pathway in various body systems. It has been demonstrated that green tea polyphenols prevent age-related neurodegeneration through improvement of endogenous antioxidant defense mechanisms, modulation of neural growth factors, attenuation of neuroinflammatory pathway, and regulation of apoptosis. The catechins exhibited beneficial effects in cellular and animal models of neurodegenerative diseases including Alzheimer’s disease, MS, and Parkinson’s disease. The present review discusses the current pharmacological targets, which can be involved in the treatment of cognitive decline and addresses the action of catechin derivatives elicited from green tea on the multiple neural targets. © 2018 Wiley Periodicals, Inc.