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Targeting Wnt Signaling Pathway by Polyphenols: Implication for Aging and Age-Related Diseases Publisher Pubmed



Maleki Dana P1 ; Sadoughi F1 ; Mansournia MA2 ; Mirzaei H1 ; Asemi Z1 ; Yousefi B3, 4
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Biogerontology Published:2021


Abstract

Age is an important risk factor for different diseases. The same mechanisms that promote aging are involved in the development and progression of age-associated diseases. Polyphenols are organic compounds found in fruits and vegetables. Due to their beneficial properties (e.g. antioxidant and anti-inflammatory), polyphenols have been extensively used for treating chronic diseases. To exert their functions, polyphenols target various molecular mechanisms and signaling pathways, such as mTOR, NF-κB, and Wnt/β-catenin. Wnt signaling is a critical pathway for developmental processes. Besides, dysregulation of this signaling pathway has been observed in various diseases. Several investigations have been conducted on Wnt inhibitors at pre-clinical stages, showing promising results. Herein, we review the studies dealing with the role of polyphenols in targeting the Wnt signaling pathways in aging processes and age-associated diseases, including cancer, diabetes, Alzheimer’s disease, osteoporosis, and Parkinson’s disease. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.
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