Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Interplay Between Gut Microbiota and Autism Spectrum Disorders: A Focus on Immunological Pathways Publisher Pubmed



Moradi K1 ; Ashrafganjouei A1 ; Tavolinejad H1 ; Bagheri S1 ; Akhondzadeh S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry Published:2021


Abstract

Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by impairments in social and cognitive activities, stereotypical and repetitive behaviors and restricted areas of interest. A remarkable proportion of ASD patients represent immune dysregulation as well as gastrointestinal complications. Hence, a novel concept has recently emerged, addressing the possible intercommunication between the brain, the immune system, the gut and its commensals. Here, we provide an overview of how gut microbes and their metabolites are associated with neurobehavioral features of ASD through various immunologic mechanisms. Moreover, we discuss the potential therapeutic options that could modify these features. © 2020 Elsevier Inc.
Related Docs
View other Related Docs
1. Role of Microbiota-Derived Short-Chain Fatty Acids in Nervous System Disorders, Biomedicine and Pharmacotherapy (2021)
2. The Immune System and Autism Spectrum Disorder: Association and Therapeutic Challenges, Acta Neurobiologiae Experimentalis (2021)
3. Prednisolone As Adjunctive Treatment to Risperidone in Children With Regressive Type of Autism Spectrum Disorder: A Randomized, Placebo-Controlled Trial, Clinical Neuropharmacology (2020)
4. Review of Clinical Studies Targeting Inflammatory Pathways for Individuals With Autism, Frontiers in Psychiatry (2019)
5. A Meta-Analysis of Pro-Inflammatory Cytokines in Autism Spectrum Disorders: Effects of Age, Gender, and Latitude, Journal of Psychiatric Research (2019)
6. Overview of the Recent Advances in Pathophysiology and Treatment for Autism, CNS and Neurological Disorders - Drug Targets (2018)
7. Chronic Acetyl-L-Carnitine Treatment Alleviates Behavioral Deficits and Neuroinflammation Through Enhancing Microbiota Derived-Scfa in Valproate Model of Autism, Biomedicine and Pharmacotherapy (2023)
8. Autism Spectrum Disorders and Natural Killer Cells: A Review on Pathogenesis and Treatment, Expert Review of Clinical Immunology (2021)
Experts (# of related papers)
View all Related Experts
Shahin Akhondzadeh Basti (13)
Mohammad Reza Mohammadi (11)
Other Related Docs
9. The Role of Intestinal Microbiota in Cognitive Disorders, Journal of Mazandaran University of Medical Sciences (2021)
10. Linking Diet and Gut Microbiota in Multiple Sclerosis, Diet and Nutrition in Neurological Disorders (2023)
11. Dietary Fiber and Aging, Nutrients and Nutraceuticals for Active and Healthy Ageing (2020)
12. Emerging Drugs for the Treatment of Irritability Associated With Autism Spectrum Disorder, Expert Opinion on Emerging Drugs (2024)
13. Minocycline As Adjunctive Treatment to Risperidone in Children With Autistic Disorder: A Randomized, Double-Blind Placebo-Controlled Trial, Journal of Child and Adolescent Psychopharmacology (2016)
14. Spondyloarthropathies and Gut Microbiota, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)
15. Does the Ketogenic Diet Improve Neurological Disorders by Influencing Gut Microbiota? a Systematic Review, Nutrition Journal (2023)
16. Modulation of Efferocytosis and Inflammation Resolution by Live and Non-Live Probiotics Through Gut Microbiota Interactions in Preclinical and Clinical Studies, Food Bioscience (2024)
17. Gut Microbiome in Multiple Sclerosis-Related Cognitive Impairment, Multiple Sclerosis and Related Disorders (2022)
18. Palmitoylethanolamide As Adjunctive Therapy for Autism: Efficacy and Safety Results From a Randomized Controlled Trial, Journal of Psychiatric Research (2018)
19. Simvastatin As an Adjunctive Therapy to Risperidone in Treatment of Autism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Journal of Child and Adolescent Psychopharmacology (2018)
20. Sulforaphane As an Adjunctive Treatment for Irritability in Children With Autism Spectrum Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Psychiatry and Clinical Neurosciences (2020)
21. Immunosuppressive Effects of Two Probiotics, Lactobacillus Paracasei Dsm 13434 and Lactobacillus Plantarum Dsm 15312, on Cd4+ T Cells of Multiple Sclerosis Patients, Iranian Journal of Allergy# Asthma and Immunology (2023)
22. The Effect of Probiotics on Immune Responses and Their Therapeutic Application: A New Treatment Option for Multiple Sclerosis, Biomedicine and Pharmacotherapy (2023)
23. Shedding Light on Biological Sex Differences and Microbiota–Gut–Brain Axis: A Comprehensive Review of Its Roles in Neuropsychiatric Disorders, Biology of Sex Differences (2022)
24. Anti-Inflammatory Cytokines in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis, Cytokine (2019)
25. A Pilot Double-Blind Placebo-Controlled Trial of Pioglitazone As Adjunctive Treatment to Risperidone: Effects on Aberrant Behavior in Children With Autism, Psychiatry Research (2015)
26. Autoimmune Diseases, Clinical Immunology (2022)
27. Intestinal Microbiota: Novel Personalized Cancer Immunotherapy in Colorectal Cancer, International Archives of Allergy and Immunology (2022)
28. Microbiota and Autism Spectrum Disorder, Avicenna Journal of Medical Biotechnology (2019)
29. Does Pregnenolone Adjunct to Risperidone Ameliorate Irritable Behavior in Adolescents With Autism Spectrum Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial?, Clinical Neuropharmacology (2020)
30. Interactive Relationship Between Trp Metabolites and Gut Microbiota: The Impact on Human Pathology of Disease, Journal of Applied Microbiology (2022)
31. L-Carnosine As an Adjunctive Therapy to Risperidone in Children With Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Child and Adolescent Psychopharmacology (2018)
32. Expression of Toll-Like Receptors 2, 4 and 5 in Relation to Gut Microbiota in Colon Neoplasm Patients With and Without Inflammatory Bowel Disease, Avicenna Journal of Medical Biotechnology (2022)
33. Risperidone Combination Therapy With Propentofylline for Treatment of Irritability in Autism Spectrum Disorders: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Clinical Neuropharmacology (2019)
34. Mind Diet Adherence Might Be Associated With a Reduced Odds of Multiple Sclerosis: Results From a Case–Control Study, Neurology and Therapy (2022)
35. Gut Microbiota: A Perspective of Precision Medicine in Endocrine Disorders, Journal of Diabetes and Metabolic Disorders (2020)
36. N-Acetylcysteine As an Adjunctive Therapy to Risperidone for Treatment of Irritability in Autism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Efficacy and Safety, Clinical Neuropharmacology (2015)
37. Assessment of Probiotics Mixture on Memory Function, Inflammation Markers, and Oxidative Stress in an Alzheimer's Disease Model of Rats, Iranian Biomedical Journal (2020)
38. The Association of Dietary Nitrates/Nitrites Intake and the Gut Microbial Metabolite Trimethylamine N-Oxide and Kynurenine in Adults: A Population-Based Study, Frontiers in Nutrition (2024)
39. Resveratrol As Adjunctive Therapy in Treatment of Irritability in Children With Autism: A Double-Blind and Placebo-Controlled Randomized Trial, Journal of Clinical Pharmacy and Therapeutics (2020)
40. Autism-Like Symptoms by Exposure to Air Pollution and Valproic Acid–Induced in Male Rats, Environmental Science and Pollution Research (2022)
41. The Contribution of Gut-Brain Axis to Development of Neurological Symptoms in Covid-19 Recovered Patients: A Hypothesis and Review of Literature, Frontiers in Cellular and Infection Microbiology (2022)
42. Extra Intestinal Manifestations of Celiac Disease and Associated Disorders, International Journal of Celiac Disease (2017)
43. Sex-Dependent Alterations of Inflammatory Factors, Oxidative Stress, and Histopathology of the Brain-Gut Axis in a Vpa-Induced Autistic-Like Model of Rats, Birth Defects Research (2024)
44. Metabolic and Epigenetic Orchestration of (Car) T Cell Fate and Function, Cancer Letters (2022)
45. Exploring the Effect of Gut Microbiome on Alzheimer's Disease, Biochemistry and Biophysics Reports (2024)
46. Nlrp3 Inflammatory Pathway. Can We Unlock Depression?, Brain Research (2024)