Spondyloarthropathies and Gut Microbiota Publisher



Soleimanifar N¹ ; Assadiasl S¹ Show Affiliations
Source: Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors Published:2021

Abstract

The effect of the gut microbiome has been demonstrated on the health and diseases of the human being. Spondyloarthropathies as a major subgroup of autoimmune disorders have also been investigated in terms of microbiota influence. Accordingly, some distinctions have been found in combination and frequency of microbial species in SpA patients gut comparing to the healthy population; however, these findings could not be usually confirmed by subsequent studies. Nonetheless, there have been some strains shown to exert immunoregulatory effects, such as Lactobacilli whereas, there are others found with more frequency in SpA patients presumed to trigger pro-inflammatory responses. Regarding the considerable role of microbiota in the development of gut immunity and tolerance induction, more studies are required to clarify the association of pathogenic and protective microbial species with the immune profile of the gastrointestinal tract. Despite the incomplete description of gut microbiota and lack of robust consensus on present findings, there have been some efforts to replace unhealthy gut microbiota with healthy species in order to restrain inflammatory responses. In the present chapter, we summarize the available findings of correlation between gut microbiota and SpAs. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.