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A Systematic Review and Meta-Analysis of Randomized Controlled Trials to Evaluating the Trend of Cytokines to Vitamin a Supplementation in Autoimmune Diseases Publisher Pubmed



Harirchian MH1 ; Mohammadpour Z1, 2 ; Fatehi F1 ; Firoozeh N1 ; Bitarafan S1
Authors
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Authors Affiliations
  1. 1. Iranian Center of Neurological Research, Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Liver Transplantation Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Clinical Nutrition Published:2019


Abstract

Background & aims: Vitamin A is considered as a supplement that effect on autoimmune diseases. We aimed to systematically review the effect of vitamin A on cytokines in patients with autoimmune disease. Methods: Two researchers searched Scopus and PubMed until May 2018. Researchers extracted data from 6 eligible published papers. Extracted data included the gene expression of the inflammatory and anti-inflammatory cytokines. Results: Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-γ and T-bet) and anti-inflammatory (TGF-β and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases. Conclusions: Vitamin A supplementation effects on gene expression and may improve serum level of cytokines and clinical signs of autoimmune disease but there is no adequate evidence. © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
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