Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1

Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1 Publisher Pubmed

Tavakoli A¹ ; Ataeipirkooh A¹ ; Mm Sadeghi G² ; Bokharaeisalim F¹ ; Sahrapour P³ ; Kiani SJ¹ ; Moghoofei M⁴ ; Farahmand M⁵ ; Javanmard D¹ ; Monavari SH¹

Show Affiliations

1. Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, 449614535, Iran
2. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, 1591634311, Iran
3. Department of Medicine, Faculty of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran
4. Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, 6716777816, Iran
5. Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417613151, Iran

Source: Nanomedicine Published:2018

Abstract

Aim: We aimed to determine the possible inhibitory effects of zinc oxide nanoparticles (ZnO-NPs) and polyethylene glycol (PEG)-coated ZnO-NPs (ZnO-PEG-NPs) on herpes simplex virus type 1 (HSV-1). Materials & methods: PEGylated ZnO-NPs were synthesized by the mechanical method. Antiviral activity was assessed by 50% tissue culture infectious dose (TCID50) and real-time PCR assays. To confirm the antiviral activity of ZnO-NPs on expression of HSV-1 antigens, indirect immunofluorescence assay was also conducted. Results: 200 μg/ml ZnO-PEG-NPs could result in 2.5 log10 TCID50 reduction in virus titer, with inhibition rate of approximately 92% in copy number of HSV-1 genomic DNA. Conclusion: ZnO-PEG-NPs could be proposed as a new agent for efficient HSV-1 inhibition. Our results indicated that PEGylation is effective in reducing cytotoxicity and increasing antiviral activity of nanoparticles. © 2018 Future Medicine Ltd.

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Style	Citing Format
MLA	Tavakoli A, et al.. "Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1." Nanomedicine, vol. 13, no. 21, 2018, pp. -.
APA	Tavakoli A, Ataeipirkooh A, Mm Sadeghi G, Bokharaeisalim F, Sahrapour P, Kiani SJ, Moghoofei M, Farahmand M, Javanmard D, Monavari SH (2018). Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1. Nanomedicine, 13(21), -.
Chicago	Tavakoli A, Ataeipirkooh A, Mm Sadeghi G, Bokharaeisalim F, Sahrapour P, Kiani SJ, Moghoofei M, Farahmand M, Javanmard D, Monavari SH. "Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1." Nanomedicine 13, no. 21 (2018): -.
Harvard	Tavakoli A et al. (2018) 'Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1', Nanomedicine, 13(21), pp. -.
Vancouver	Tavakoli A, Ataeipirkooh A, Mm Sadeghi G, Bokharaeisalim F, Sahrapour P, Kiani SJ, et al.. Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1. Nanomedicine. 2018;13(21):-.
BibTex	@article{ author = {Tavakoli A and Ataeipirkooh A and Mm Sadeghi G and Bokharaeisalim F and Sahrapour P and Kiani SJ and Moghoofei M and Farahmand M and Javanmard D and Monavari SH}, title = {Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1}, journal = {Nanomedicine}, volume = {13}, number = {21}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Tavakoli A AU - Ataeipirkooh A AU - Mm Sadeghi G AU - Bokharaeisalim F AU - Sahrapour P AU - Kiani SJ AU - Moghoofei M AU - Farahmand M AU - Javanmard D AU - Monavari SH TI - Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1 JO - Nanomedicine VL - 13 IS - 21 SP - EP - PY - 2018 ER -

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