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Nanostructures for Prevention, Diagnosis, and Treatment of Viral Respiratory Infections: From Influenza Virus to Sars-Cov-2 Variants Publisher Pubmed



Sharifi E1 ; Yousefiasl S2 ; Trovato M3 ; Sartorius R3 ; Esmaeili Y4 ; Goodarzi H5, 6 ; Ghomi M7 ; Bigham A1 ; Moghaddam FD8 ; Heidarifard M5, 6 ; Pourmotabed S9 ; Nazarzadeh Zare E7 ; Paivasantos AC10, 11 ; Rabiee N12, 13 Show All Authors
Authors
  1. Sharifi E1
  2. Yousefiasl S2
  3. Trovato M3
  4. Sartorius R3
  5. Esmaeili Y4
  6. Goodarzi H5, 6
  7. Ghomi M7
  8. Bigham A1
  9. Moghaddam FD8
  10. Heidarifard M5, 6
  11. Pourmotabed S9
  12. Nazarzadeh Zare E7
  13. Paivasantos AC10, 11
  14. Rabiee N12, 13
  15. Wang X14
  16. Tay FR15

Source: Journal of Nanobiotechnology Published:2023


Abstract

Viruses are a major cause of mortality and socio-economic downfall despite the plethora of biopharmaceuticals designed for their eradication. Conventional antiviral therapies are often ineffective. Live-attenuated vaccines can pose a safety risk due to the possibility of pathogen reversion, whereas inactivated viral vaccines and subunit vaccines do not generate robust and sustained immune responses. Recent studies have demonstrated the potential of strategies that combine nanotechnology concepts with the diagnosis, prevention, and treatment of viral infectious diseases. The present review provides a comprehensive introduction to the different strains of viruses involved in respiratory diseases and presents an overview of recent advances in the diagnosis and treatment of viral infections based on nanotechnology concepts and applications. Discussions in diagnostic/therapeutic nanotechnology-based approaches will be focused on H1N1 influenza, respiratory syncytial virus, human parainfluenza virus type 3 infections, as well as COVID-19 infections caused by the SARS-CoV-2 virus Delta variant and new emerging Omicron variant. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).
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