Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Potentiometric Determination of Betahistine in Pharmaceutical Formulations by Drug Selective Sensors



Ganjali MR1, 2 ; Aghili S1 ; Larijani B3 ; Ghasemi MH4
Authors

Source: International Journal of Electrochemical Science Published:2015

Abstract

Betahistine is histamine like drug that acts as both a partial histamine H1 receptor agonist and as a histamine H3 receptor antagonist. This research introduces design and construction of a PVC membrane sensor and nano-composite carbon paste electrode for fast and simple determination of Betahistine in pharmaceutical formulation. The best electrode performance was obtained with a membrane composition of 30% PVC, 63% NPOE, and 7% ion-pair and paste composition of 53% graphite, 30% paraffin oil, 15% ion-pair and 2% MWCNT. This electrode illustrated fast, stable and Nernstian response over a relatively wide concentration range of 1×10-5 to 1×10-2 mol L-1 for PVC membrane sensor and 1.0×10-6 to 5.0×10-1 mol L-1 for nano-composite carbon paste electrode. Validation of the method shows suitability of the sensors for application in quality control analysis of drug in pharmaceutical formulation. © 2015 The Authors.
Related Docs
View other Related Docs
1. Simultaneous Voltammetric Determination of Mefenamic Acid and Paracetamol Using Graphene Nanosheets/Nickel Oxide Nanoparticles Modified Carbon Paste Electrode, Journal of Electrochemical Science and Technology (2017)
2. A New Carbon Paste Electrode Modified With Mwcnts and Nano-Structured Molecularly Imprinted Polymer for Ultratrace Determination of Trimipramine: The Crucial Effect of Electrode Components Mixing on Its Performance, Biosensors and Bioelectronics (2018)
3. Applications of Carbon-Based Conductive Nanomaterials in Biosensors, Chemical Engineering Journal (2022)
Experts (# of related papers)
View all Related Experts
Ali Mohammadi (2)
Seyed Jamaledin Shataheri (1)
Other Related Docs
4. Modification of Carbon Paste Electrode Based on Molecularly Imprinted Polymer for Electrochemical Determination of Diazinon in Biological and Environmental Samples, Electroanalysis (2017)
5. Simultaneous Electrochemical Determination of Isoniazid and Ethambutol Using Poly-Melamine/Electrodeposited Gold Nanoparticles Modified Pre-Anodized Glassy Carbon Electrode, Ionics (2018)
6. An Electrochemical Sensor Based on Poly (L-Cysteine)@Aunps @ Reduced Graphene Oxide Nanocomposite for Determination of Levofloxacin, Microchemical Journal (2019)
7. Measurement of Some Amino Acid Using Biosensors Based on Silicon-Based Carbon Nanotubes, Journal of Computational and Theoretical Nanoscience (2019)
8. Performance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum, IEEE Sensors Journal (2018)
9. Selective Determination of Levodopa in the Presence of Vitamin B 6 , Theophylline and Guaifenesin Using a Glassy Carbon Electrode Modified With a Composite of Hematoxylin and Graphene/Zno, Analytical Sciences (2018)
10. Electrochemical Platform for Simultaneous Determination of Levodopa, Acetaminophen and Tyrosine Using a Graphene and Ferrocene Modified Carbon Paste Electrode, Microchimica Acta (2017)
11. Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified With Functionalized Graphene Oxide Nanosheets Within a Fe3o4@Sio2 Nanocomposite, Iranian Journal of Pharmaceutical Research (2019)
12. Facile Electrochemical Preparation of Overoxidizedpolypyrrole/Rgo Composite for Ds-Dna Immobilization: A Novel Signal Amplified Sensing Platform for Electrochemical Determination of Chlorpheniramine, DARU# Journal of Pharmaceutical Sciences (2020)
13. Electrochemical Determination of the Antipsychotic Medication Clozapine by a Carbon Paste Electrode Modified With a Nanostructure Prepared From Titania Nanoparticles and Copper Oxide, Microchimica Acta (2019)
14. All Solid Sate Potentiometric Sensors for the Measurement of Paroxetine in Pharmaceutical Formulation, International Journal of Electrochemical Science (2015)
15. Electrochemical Determination of Methyldopa by Graphene Quantum Dot / 1-Butyl-3-Methylimidazolium Hexafluoro Phosphate Nanocomposite Electrode, International Journal of Electrochemical Science (2017)
16. All Solid Sate Potentiometric Sensors for Granisetron Hydrochloride in Pharmaceutical Formulation, Analytical and Bioanalytical Electrochemistry (2017)
17. Label-Free Electrochemical Immunosensor Based on Electrodeposited Prussian Blue and Gold Nanoparticles for Sensitive Detection of Citrus Bacterial Canker Disease, Sensors and Actuators# B: Chemical (2018)
18. Design and Construction of New Potentiometric Sensors for Determination of Al3 + Ion Based on (Z)-2-(2-Methyl Benzylidene)-1-(2,4-Dinitrophenyl) Hydrazine, Materials Science and Engineering C (2015)
19. Electrochemical Sensing Platform Based on Graphene Oxide-Chitosan for Simultaneous Determination of Some Antihypertensive Drugs, Electroanalysis (2023)
20. Development of an Admittance Sensor for Isoniazid Using Differential Coulometric Fft Admittance Voltammetry in a Flow Injection Analysis System, Analytical and Bioanalytical Electrochemistry (2017)