Clenbuterol Determination in Pharmaceutical Formulation by Potentiometric Membrane Sensor



Faridbod F^{1, 2} ; Dorrani M¹
Source: International Journal of Electrochemical Science Published:2015

Abstract

Clenbuterol is a selective β2-adrenoceptor agonist which has been known as a thermogenic drug. This work introduces design and construction of a PVC membrane sensor for fast and simple determination of Clenbuterol in pharmaceutical formulation. The designed electrochemical sensor responds based on ion-pair exchange mechanism. Clenbuterol-Tetraphenyl borate was synthesized and used as sensing element of the membrane. After a series of experiments, the best electrode performance was selected with a membrane composition of 30% PVC, 60% DBP, 2% room temperature ionic liquid and 8% ion-pair. Room temperature ionic liquid was used as an additive and improves the sensitivity of the sensor. This electrode has a rather fast (~34 s), stable and Nernstian response (57.5±0.4 mV/decade) in a wide concentration range of 5.3×10-6 to 1×10-2 mol L-1, and applicable pH range of 3-6. Validation of the method shows suitability of the sensors for analysis of Clenbuterol in pharmaceutical tablets. The sensor shows good repeatability with RSD of 4.7%. © 2015 The Authors.