Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Review on Advances in Graphene-Derivative/Polysaccharide Bionanocomposites: Therapeutics, Pharmacogenomics and Toxicity Publisher Pubmed



Makvandi P1, 2 ; Ghomi M3 ; Ashrafizadeh M4 ; Tafazoli A5 ; Agarwal T6 ; Delfi M7 ; Akhtari J8 ; Zare EN9 ; Padil VVT10 ; Zarrabi A11, 12 ; Pourreza N3 ; Miltyk W5 ; Maiti TK6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Istituto Italiano di Tecnologia, Centre for Micro-BioRobotics, viale Rinaldo Piaggio 34, Pontedera, 56025, Pisa, Italy
  2. 2. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 14496-14535, Iran
  3. 3. Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, 6153753843, Iran
  4. 4. Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, 51666-16471, Iran
  5. 5. Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Bialystok, 15-089, Poland
  6. 6. Department of Biotechnology, Indian Institute of Technology, Kharagpur, 721302, India
  7. 7. Department of Chemical Sciences, University of Naples “Federico II�, Naples, 80126, Italy
  8. 8. Toxoplasmosis Research Center, Communicable Diseases Institute, Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  9. 9. School of Chemistry, Damghan University, Damghan, 36716-41167, Iran
  10. 10. Department of Nanomaterials in Natural Sciences, Institute for Nanomaterials, Advanced Technologies and Innovation (CXI), Technical University of Liberec (TUL), Studentska, 1402/2, Liberec, Czech Republic
  11. 11. Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, Turkey
  12. 12. Center of Excellence for Functional Surfaces and Interfaces (EFSUN), Faculty of Engineering and Natural Sciences, Sabanci University, Tuzla, Istanbul, 34956, Turkey

Source: Carbohydrate Polymers Published:2020


Abstract

Graphene-based bionanocomposites are employed in several ailments, such as cancers and infectious diseases, due to their large surface area (to carry drugs), photothermal properties, and ease of their functionalization (owing to their active groups). Modification of graphene-derivatives with polysaccharides is a promising strategy to decrease their toxicity and improve target ability, which consequently enhances their biotherapeutic efficacy. Herein, functionalization of graphene-based materials with carbohydrate polymers (e.g., chitosan, starch, alginate, hyaluronic acid, and cellulose) are presented. Subsequently, recent advances in graphene nanomaterial/polysaccharide-based bionanocomposites in infection treatment and cancer therapy are comprehensively discussed. Pharmacogenomic and toxicity assessments for these bionanocomposites are also highlighted to provide insight for future optimized and smart investigations and researches. © 2020 Elsevier Ltd
Related Docs
View other Related Docs
1. An Overview on the Reproductive Toxicity of Graphene Derivatives: Highlighting the Importance, Nanotechnology Reviews (2022)
2. Graphene Oxide Nanoarchitectures in Cancer Therapy: Drug and Gene Delivery, Phototherapy, Immunotherapy, and Vaccine Development, Environmental Research (2023)
3. Apigenin As Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer, Frontiers in Chemistry (2020)
4. Codelivery of Hydrophobic and Hydrophilic Drugs by Graphene-Decorated Magnetic Dendrimers, Langmuir (2018)
5. Recent Advances and Trends in Nanoparticles Based Photothermal and Photodynamic Therapy, Photodiagnosis and Photodynamic Therapy (2022)
6. Advances in Biogenically Synthesized Shaped Metal- and Carbon-Based Nanoarchitectures and Their Medicinal Applications, Advances in Colloid and Interface Science (2020)
7. Graphene-Based Nanomaterials for Stimuli-Sensitive Controlled Delivery of Therapeutic Molecules, Frontiers in Bioengineering and Biotechnology (2023)
8. Systems Toxicology Assessment Revealed the Impact of Graphene-Based Materials on Cell Cycle Regulators, Journal of Biomedical Materials Research - Part A (2020)
Experts (# of related papers)
View all Related Experts
Mona Navaei-Nigjeh (3)
Nima Rezaei (1)
Other Related Docs
9. Graphene-Based Polymer Nanocomposites: Chemistry and Applications, Advanced Structured Materials (2015)
10. Targeting Autophagy in Prostate Cancer: Preclinical and Clinical Evidence for Therapeutic Response, Journal of Experimental and Clinical Cancer Research (2022)
11. Bio-Applications of Graphene Composites: From Bench to Clinic, Advanced 2D Materials (2016)
12. Resveratrol in Breast Cancer Treatment: From Cellular Effects to Molecular Mechanisms of Action, Cellular and Molecular Life Sciences (2022)
13. Steric Stabilization of Β-Cyclodextrin Functionalized Graphene Oxide by Host-Guest Chemistry: A Versatile Supramolecule for Dual-Stimuli Responsive Cellular Delivery of Doxorubicin, Journal of Drug Delivery Science and Technology (2021)
14. Occupational Exposure to Nanomaterials: Hazards, Toxicity and Safety Concerns, Nanomaterials in Industrial Chemistry (2024)
15. 3D Self-Assembled Nanocarriers for Drug Delivery, Drug Metabolism Reviews (2023)
16. In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy, Journal of Controlled Release (2020)
17. Graphene Aerogel Nanoparticles for In-Situ Loading/Ph Sensitive Releasing Anticancer Drugs, Colloids and Surfaces B: Biointerfaces (2020)
18. Bio-Multifunctional Noncovalent Porphyrin Functionalized Carbon-Based Nanocomposite, Scientific Reports (2021)
19. Immobilization of L-Asparaginase on Aspartic Acid Functionalized Graphene Oxide Nanosheet: Enzyme Kinetics and Stability Studies, Chemical Engineering Journal (2018)
20. Synthesis and Characterization of a Novel, Ph-Responsive Sustained Release Nanocarrier Using Polyethylene Glycol, Graphene Oxide, and Natural Silk Fibroin Protein by a Green Nano Emulsification Method to Enhance Cancer Treatment, International Journal of Biological Macromolecules (2023)
21. Epigenetic Effects of Graphene Oxide and Its Derivatives: A Mini-Review, Mutation Research - Genetic Toxicology and Environmental Mutagenesis (2022)
22. Green and Sustainable Hydrogels Based on Quaternized Chitosan to Enhance Wound Healing, Chemical Engineering Journal (2024)
23. Development of a New Electroconductive Nanofibrous Cardiac Patch Based on Polyurethane-Reduced Graphene Oxide Nanocomposite Scaffolds, Materials Chemistry and Physics (2023)
24. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)
25. Mechanistic Understanding of the Interactions Between Nano-Objects With Different Surface Properties and Α-Synuclein, ACS Nano (2019)
26. The Role of Cell Membrane-Coated Nanoparticles As a Novel Treatment Approach in Glioblastoma, Frontiers in Molecular Biosciences (2023)
27. Anti-Cancer Activity of New Phosphoramide-Functionalized Graphene Oxides: An Experimental and Theoretical Evaluation, Current Medicinal Chemistry (2023)
28. Bone Tissue Engineering Gelatin–Hydroxyapatite/Graphene Oxide Scaffolds With the Ability to Release Vitamin D: Fabrication, Characterization, and in Vitro Study, Journal of Materials Science: Materials in Medicine (2020)
29. A Review on Drug Delivery Systems Containing Polymer Nanocomposites for Breast Cancer Treatment, Polymer Reviews (2024)
30. Hierarchical Multifunctional Graphene Oxide Cancer Nanotheranostics Agent for Synchronous Switchable Fluorescence Imaging and Chemical Therapy, Microchimica Acta (2020)
31. Evaluation of the Photothermal Properties of a Reduced Graphene Oxide/Arginine Nanostructure for Near-Infrared Absorption, ACS Applied Materials and Interfaces (2017)
32. The Neurotoxic Mechanisms of Graphene Family Nanomaterials at the Cellular Level: A Solution-Based Approach Review, Current Pharmaceutical Design (2022)
33. Functionalized Nanomaterial for Environmental Techniques, Nanotechnology in Environmental Science (2018)
34. Controlled Anti-Cancer Drug Release Through Advanced Nano-Drug Delivery Systems: Static and Dynamic Targeting Strategies, Journal of Controlled Release (2020)
35. Mof As Nanoscale Drug Delivery Devices: Synthesis and Recent Progress in Biomedical Applications, Journal of Drug Delivery Science and Technology (2023)
36. Porous Carbon-Based Material As a Sustainable Alternative for the Storage of Natural Gas (Methane) and Biogas (Biomethane): A Review, Chemical Engineering Journal (2022)
37. Dna Technologies in Precision Medicine and Pharmacogenetics, Precision Medicine in Clinical Practice (2022)
38. Metal-Based Nanostructures/Plga Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications, ACS Applied Materials and Interfaces (2020)
39. Assessment of Synthesized Chitosan/Halloysite Nanocarrier Modified by Carbon Nanotube for Ph-Sensitive Delivery of Curcumin to Cancerous Media, International Journal of Biological Macromolecules (2023)
40. Incorporation of Two-Dimensional Nanomaterials Into Silk Fibroin Nanofibers for Cardiac Tissue Engineering, Polymers for Advanced Technologies (2020)
41. Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review, Current Molecular Pharmacology (2021)
42. Deciphering the Transcription Factor-Microrna-Target Gene Regulatory Network Associated With Graphene Oxide Cytotoxicity, Nanotoxicology (2018)
43. Hb5 Aptamer-Tagged Graphene Oxide for Co-Delivery of Doxorubicin and Silibinin, and Highly Effective Combination Therapy in Breast Cancer, Cancer Nanotechnology (2023)