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Association of Il-6 -176G > C Polymorphism With Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis Publisher Pubmed



Veisian M1 ; Javaheri A2 ; Amjadi N3 ; Tabatabaei RS2 ; Zanbagh L2, 4 ; Hadadan A2, 3 ; Abbasi H3 ; Salimi E3 ; Dastgheib SA5 ; Neamatzadeh H6, 7
Authors

Source: Fetal and Pediatric Pathology Published:2020


Abstract

Background: Many studies have described the influence of -176G > C polymorphism of the IL-6 gene on susceptibility to preeclampsia. However, the results have remained inconclusive and controversial. Therefore, we performed a meta-analysis to more precisely determine the association between the IL-6 -176G > C polymorphism and preeclampsia risk. Methods: Electronic databases including PubMed, Embase, Web of Science, and CNKI were searched up to August 15, 2019. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to calculate the association. Results: A total of 12 studies with 1,821 preeclampsia cases and 3,339 controls were selected. Overall, no significant association was found between IL-6 -176G > C polymorphism and preeclampsia risk. In the stratified analyses by ethnicity, there was a significant association in Asians, but not in Caucasians and mixed populations. Conclusions: The results of meta-analysis indicated that IL-6 -176G > C polymorphism was not significantly associated with risk of preeclampsia in overall population. © 2019 Taylor & Francis Group, LLC.
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