The Emerging Roles of Lncrnas As a Novel Player in the Pathogenesis of Preeclampsia Publisher



Shabani M¹ ; Eghbali M² ; Hoorzad P³ ; Karamipour S¹ ; Hosseini SM¹ ; Abiri A⁴ ; Abiri M^{1, 5} Show Affiliations
Source: Gene Reports Published:2023

Abstract

Preeclampsia (PE) is a pregnancy-related multisystem disorder that is characterized by hypertension and proteinuria after the 20th week of gestation. Although multiple factors are found to be associated with the risk of preeclampsia, the exact pathogenic reason remained unclear. Accumulated data revealed that lncRNAs are dysregulated in the placenta of preeclampsia patients and they alter trophoblast cellular features including apoptosis, migration, proliferation, and invasion. The current review deals with the recently published data about lncRNAs involved in the pathogenesis of preeclampsia. It provides detailed information on three different sections. First, function and regulation of cancer-related lncRNAs associated with PE, second, lncRNAs discovered by transcriptome analysis and third part will discuss lncRNAs acting through miRNA-lncRNA interaction. lncRNAs could exert an impact on the pathogenesis of PE through the change in biological functions, epigenetic regulation, miRNA-related gene regulation and signaling pathways (including Notch1, HIF1α, PI3K/AKT). Therefore, based on these important roles, some lncRNAs can act as a biomarker of PE. © 2023