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Repair of Injured Spinal Cord Using Platelet-Rich Plasma- and Endometrial Stem Cells-Loaded Chitosan Scaffolds Publisher



Ai J1, 2 ; Farzin A2 ; Zamiri S3 ; Hadjighassem M1, 2 ; Ebrahimibarough S2 ; Ai A4 ; Mohandesnezhad S2 ; Karampour A2 ; Sagharjoghi Farahani M1 ; Goodarzi A5
Authors
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Authors Affiliations
  1. 1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Kinesiology and Health Department, York University, Toronto, Canada
  4. 4. School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2021


Abstract

Engineering scaffolds that can not only act as a vehicle for stem cell delivery but also support axon regeneration, may significantly improve the treatment outcome of spinal cord injury (SCI). In this study, we developed chitosan scaffold containing human endometrial stem cells (hEnSCs) and platelet-rich plasma (PRP) to provide a controlled environment for facilitating cell ingrowth and differentiation and also to persuade axon nervous tissue repair. The results showed that 80 µL PRP-loaded chitosan scaffold has excellent hEnSCs viability and can promote the regeneration of nerve fibers and angiogenesis and prevent the formation of scar tissue in the repair of SCI. © 2020 Taylor & Francis Group, LLC.
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