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Preliminary Results of Effect of Barley (Hordeum Vulgare L.) Extract on Liver, Pancreas, Kidneys and Cardiac Tissues in Streptozotocin Induced Diabetic Rats Publisher



Naseri M1, 2, 3 ; Sereshki ZK4 ; Ghavami B5 ; Zangii BM6 ; Kamalinejad M7 ; Moghaddam PM8 ; Asghari M9 ; Hasheminejad SA1, 2 ; Emadi F1, 2 ; Ghaffari F10
Authors
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Authors Affiliations
  1. 1. Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran
  2. 2. Department of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran, Iran
  3. 3. Hikmat, Islamic and Traditional Medicine Department, The Academy of Medical Sciences, Tehran, Iran
  4. 4. Department of Gynecology, School of Medicine, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gynecology, School of Medicine, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Histology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  9. 9. School of Persian Medicine, Qom University of Medical Sciences, Qom, Iran
  10. 10. School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: European Journal of Translational Myology Published:2022


Abstract

Diabetes mellitus (DM) and its complications impose a significant burden on patients and the health care system. In the Traditional Persian Medicine (TPM), barley is recommended for treatment of DM. This study sought to assess the effect of barley seed aqueous extract on hepatic, pancreatic, renal and cardiac tissues in normal (non-diabetic) and Streptozotocin-induced diabetic rats. Twenty-one male Wistar rats were randomly divided into diabetic and non-diabetic groups. Diabetes was induced by single intraperitoneal injection of Streptozotocin. After one week, the diabetic and non-diabetic groups were randomly divided into control and barley seed extract subgroups namely N group (non-diabetic control rats), S group (seed extract treated non-diabetic rats), D group (diabetic control rats) and DS group (seed extract treated diabetic rats). After 6 weeks, all rats were sacrificed for histopathological analysis and specimens were stained routinely for histological studies. The abnormal histological signs significantly decreased in the DS group compared to D group. Also, protective effects of barley seed extract against histopathological changes were seen in S group compared to N group.These findings suggest that barley seed extract exerts a protective effect on different tissues in diabetes. © 2022 PAGEPress Publications. All rights reserved.
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