Periodontitis and Mediterranean Fever: A Systematic Review and Meta-Analysis Publisher Pubmed



Vahed IE ; Mottaghi M ; Khamisi N ; Shirinzadeh T ; Mosadeghi K ; Almadi E ; Omran SS ; Hedayatpour R ; Aalizadeh M ; Shahre Babad ZM ; Malek M ; Rahmanian M
Source: Quintessence International Published:2025

Abstract

Objective: Periodontitis is a severe oral health condition that damages the supporting bone and soft tissues surrounding the teeth. In recent years, it has become evident that periodontitis could increase systemic inflammatory markers. Some studies showed a potential link between periodontitis and autoinflam matory diseases, including familial Mediterranean fever (FMF), which is a hereditary autoinflammatory condition. The current study aimed to comprehensively evaluate the association be tween FMF and periodontitis by analyzing clinical periodontal parameters—Plaque Index, Gingival Index, and clinical attach ment loss—through a meta-analysis. Method and materials: A thorough search was conducted across different databases, including PubMed, Scopus, Web of Science, and Google Scholar, covering publications up to July 2024. Eleven studies were included, consisting of one cohort and ten case controls. Following established methods, data extraction and quality assessment of the selected publications were performed. A meta-analysis was conducted to gather the effect sizes ob tained from the eligible publications. Results: The meta-analy sis highlighted a statistically significant increase in Plaque In dex among FMF patients compared to controls, with a pooled mean difference of 0.1833 (95% CI 0.0012 to 0.3655; P =.0485), indicating higher plaque accumulation in FMF patients. On the other hand, clinical attachment loss exhibited a nonsignificant mean difference of –0.0933 (95% CI –0.2928 to 0.1062; P =.3596), and the Gingival Index similarly did not reach statistical signif icance, presenting a mean difference of 0.3223 (95% CI –0.0713 to 0.7158; P =.1085). Conclusion: This investigation under scores a potential association between FMF and periodontitis, as seen by elevated levels of plaque in FMF patients. These re sults suggest that FMF patients experience higher levels of peri odontal inflammation, emphasizing the importance of peri odontal care in this population. © 2025 Elsevier B.V., All rights reserved.