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Genetic Susceptibility of Covid-19: A Systematic Review of Current Evidence Publisher Pubmed



Seyedalinaghi SA1 ; Mehrtak M2 ; Mohssenipour M1 ; Mirzapour P1 ; Barzegary A3 ; Habibi P1 ; Moradmandbadie B4 ; Afsahi AM5 ; Karimi A6 ; Heydari M7 ; Mehraeen E7 ; Dadras O8 ; Sabatier JM9 ; Voltarelli F10
Authors
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Authors Affiliations
  1. 1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Healthcare Services Management, School of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran
  3. 3. School of Medicine, Islamic Azad University, Tehran, Iran
  4. 4. Black Dog Institute, University of New South Wales, Sydney, Australia
  5. 5. Department of Radiology, School of Medicine, University of California, San Diego (UCSD), San Diego, CA, United States
  6. 6. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, 1419733141, Iran
  8. 8. Department of Global Health and Socioepidemiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  9. 9. Institut deNeuro-Physiopathologie (INP), UMR 7051, Faculte de Pharmacie, Universite Aix-Marseille, 27 Bd Jean Moulin, Marseille Cedex, 13385, France
  10. 10. Graduation Program of Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiaba, Brazil

Source: European Journal of Medical Research Published:2021


Abstract

Introduction: While COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma, elderly age, being pregnant, having any underlying diseases such as cardiovascular disease, diabetes, obesity, and experiencing lifelong systemic racism. Recently, connections to certain genes have also been found, although the susceptibility has not yet been established. We aimed to investigate the available evidence for the genetic susceptibility to COVID-19. Methods: This study was a systematic review of current evidence to investigate the genetic susceptibility of COVID-19. By systematic search and utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct, we retrieved all the related papers and reports published in English from December 2019 to September 2020. Results: According to the findings, COVID-19 uses the angiotensin-converting enzyme 2 (ACE2) receptor for cell entry. Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection. Also, two studies have shown that males are more likely to become infected with SARS-CoV-2 than females. Besides, research has also shown that patients possessing HLA-B*15:03 genotype may become immune to the infection. Conclusion: Combing through the genome, several genes related to immune system’s response were related to the severity and susceptibility to the COVID-19. In conclusion, a correlation was found between the ACE2 levels and the susceptibility to SARS-CoV-2 infection. © 2021, The Author(s).
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