Evaluation of the Possible Association of Znf804a Variant Rs7597593 With Bipolar Disorder in an Iranian Population Publisher



M Zobeiry MAHSA ; M Razafsha MOHSEN ; H Mohaghghegh HOORIE ; Es Ananloo Esmaeil SHAHSAVAND
Source: Gene Reports Published:2025

Abstract

Objective: To evaluate the association between the selected zinc finger protein 804 A gene (ZNF804A) variant (rs7597593) with bipolar disorder (BD) in an Iranian population. Participants and Methods: The single nucleotide polymorphism rs7597593 was genotyped in 260 participants (i.e., 130 BD patients and 130 healthy controls). Cognitive impairments were assessed by the Wechsler Adult Intelligence Scale (WAIS) for intelligence quotient (IQ); including verbal, performance, and total IQs. Results: Verbal, performance, and total IQs were significantly lower in BD patients, irrespective of sex (all P < .001). The T allele was significantly more frequent in BD participants regardless of their sex (P < .001). Similarly, the TT genotype of rs7597593 was significantly more prevalent in BD patients in all three models of co-dominant, dominant, and recessive inheritance (all P < .001). When stratified based on sex, the TT genotype was significantly more prevalent in the co-dominant inheritance in both sexes (P < .001), recessive inheritance in male patients (P < .001), and dominant inheritance in female patients (P < .001). Conclusion: Our study showed that the T allele and the TT genotype of rs7597593 of the ZNF804A gene were over-represented in BD cases in the Iranian population. Presumably, the T allele is associated with an increased risk of BD. © 2025 Elsevier B.V., All rights reserved.