Dna Methylation of Cd70 Promoter in Juvenile Systemic Lupus Erythematosus Publisher Pubmed



Keshavarzfathi M^{1, 2} ; Sanati G³ ; Sadr M⁴ ; Mohebbi B⁴ ; Ziaee V^{5, 6} ; Rezaei N^{4, 7, 8}
Source: Fetal and Pediatric Pathology Published:2022

Abstract

Introduction: Epigenetic alterations in pathogenesis of systemic lupus erythematosus (SLE) have gained more attention recently in adults. We assessed the methylation of CD70 promoter, a costimulatory molecule on T cells, in juvenile SLE (JSLE), and compared this to that found in controls and the literature of adult SLE patients. Methods: DNA methylation status was evaluated on peripheral blood from JSLE patients and healthy controls. Results: Twenty-five patients with JSLE and 24 healthy controls were compared. JSLE patients had lower unmethylated CpG islands compared to the control group (mean ± SD; 0.78 ± 0.42 vs 10503.80 ± 39796.95). However, the difference was not significant (P-value; 0.22). Conclusion: Despite hypomethylation of CD70 gene promoter in CD4+ T-cells from adult patients with SLE, no statistically significant differences observed in patients with JSLE compared with healthy controls. This may suggest a mechanism different in JSLE patients than in adults. © 2020 Taylor & Francis Group, LLC.