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Antigenic Targets of Car T Cell Therapy. a Retrospective View on Clinical Trials Publisher Pubmed



Arabi F1 ; Torabirahvar M1 ; Shariati A1 ; Ahmadbeigi N2 ; Naderi M2
Authors
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Authors Affiliations
  1. 1. SABZ Biomedicals Science-Based Company, Tehran, Iran
  2. 2. Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Ave, Tehran, 14117, Iran

Source: Experimental Cell Research Published:2018


Abstract

Chimeric antigen receptor (CAR) T cell therapy is anticipated to be increasingly implemented in the context of cancer treatment after two current FDA approval of anti-CD19 CAR-T cells (Kymriah™ & Yescarta™). The success of CD19 is mainly attributable to the proper selection of the antigen, CD19, as the target of the disease, highlighting the importance of target selection for other CAR therapies. Therefore, here we performed a global analysis of targets that are the prime focus for various CAR T cell therapies in human clinical trials. © 2018 Elsevier Inc.
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