Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Buccal Fat Pad As a Potential Source of Stem Cells for Bone Regeneration: A Literature Review Publisher



Salehinik N1 ; Rezai Rad M2 ; Kheiri L3 ; Nazeman P2 ; Nadjmi N4 ; Khojasteh A1, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. University of Antwerp, The Team for Cleft and Craniofacial Anomalies, Oral and Maxillofacial Surgery, University of Antwerp, Antwerp, Belgium
  5. 5. Medical Nano-Technology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Medicine, University of Antwerp, Antwerp, Belgium

Source: Stem Cells International Published:2017


Abstract

Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuses on the characteristics and osteogenic capability of stem cells derived from BFP as a valuable cell source for bone tissue engineering. An electronic search was performed on all in vitro and in vivo studies that used stem cells from BFP for the purpose of bone tissue engineering from 2010 until 2016. This review was organized according to the PRISMA statement. Adipose-derived stem cells derived from BFP (BFPSCs) were compared with adipose tissues from other parts of the body (AdSCs). Moreover, the osteogenic capability of dedifferentiated fat cells (DFAT) derived from BFP (BFP-DFAT) has been reported in comparison with BFPSCs. BFP is an easily accessible source of stem cells that can be obtained via the oral cavity without injury to the external body surface. Comparing BFPSCs with AdSCs indicated similar cell yield, morphology, and multilineage differentiation. However, BFPSCs proliferate faster and are more prone to producing colonies than AdSCs. © 2017 Nasim Salehi-Nik et al.
Related Docs
View other Related Docs
1. Impact of Tissue Harvesting Sites on the Cellular Behaviors of Adipose-Derived Stem Cells: Implication for Bone Tissue Engineering, Stem Cells International (2017)
2. Buccal Fat Pad–Derived Stem Cells in Three-Dimensional Rehabilitation of Large Alveolar Defects: A Report of Two Cases, Journal of Oral Implantology (2019)
3. Buccal Fat Pad-Derived Stem Cells With Anorganic Bovine Bone Mineral Scaffold for Augmentation of Atrophic Posterior Mandible: An Exploratory Prospective Clinical Study, Clinical Implant Dentistry and Related Research (2019)
4. Multipotent Stem Cell and Current Application, Acta Medica Iranica (2017)
5. Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application, Frontiers in Cell and Developmental Biology (2020)
6. Application of Selected Scaffolds for Bone Tissue Engineering: A Systematic Review, Oral and Maxillofacial Surgery (2017)
7. In Vitro Osteogenic Differentiation of Stem Cells With Different Sources on Composite Scaffold Containing Natural Bioceramic and Polycaprolactone, Artificial Cells# Nanomedicine and Biotechnology (2019)
8. Bone Tissue Engineering Using Human Cells: A Comprehensive Review on Recent Trends, Current Prospects, and Recommendations, Applied Sciences (Switzerland) (2019)
Experts (# of related papers)
View all Related Experts
Hamidreza Aghayan (4)
Mohammad Ali Nilforoushzadeh (4)
Other Related Docs
9. The Clinical Trials of Mesenchymal Stromal Cells Therapy, Stem Cells International (2021)
10. Bone Tissue Engineering: Adult Stem Cells in Combination With Electrospun Nanofibrous Scaffolds, Journal of Cellular Physiology (2018)
11. Adipose Tissue-Derived Stromal Cells for Wound Healing, Advances in Experimental Medicine and Biology (2018)
12. Adipose-Derived Stem Cells: Potentials, Availability and Market Size in Regenerative Medicine, Current Stem Cell Research and Therapy (2023)
13. Nanotopographical Cues of Electrospun Plla Efficiently Modulate Non-Coding Rna Network to Osteogenic Differentiation of Mesenchymal Stem Cells During Bmp Signaling Pathway, Materials Science and Engineering C (2018)
14. Literature Review of Adipose-Derived Mesanchymal Cells From History to Approaches, Iranian Red Crescent Medical Journal (2017)
15. Concomitant Transurethral and Transvaginal-Periurethral Injection of Autologous Adipose Derived Stem Cells for Treatment of Female Stress Urinary Incontinence: A Phase One Clinical Trial, Acta Medica Iranica (2017)
16. Biophysical Evaluation of Treating Adipose Tissue-Derived Stem Cells Using Non-Thermal Atmospheric Pressure Plasma, Scientific Reports (2022)
17. The Clinical Trials of Mesenchymal Stem Cell Therapy in Skin Diseases: An Update and Concise Review, Current Stem Cell Research and Therapy (2019)
18. Transplantation of Adipose Derived Stem Cells in Diabetes Mellitus; Limitations and Achievements, Journal of Diabetes and Metabolic Disorders (2023)
19. Bladder Dysfunction, Stem Cells in Urology (2020)
20. The Combined Application of Human Adipose Derived Stem Cells and Chondroitinase Abc in Treatment of a Spinal Cord Injury Model, Neuropeptides (2017)
21. Wound Healing Improvement by Curcumin-Loaded Electrospun Nanofibers and Bfp-Mscs As a Bioactive Dressing, Polymers for Advanced Technologies (2020)
22. Evaluation and Comparison of the in Vitro Characteristics and Chondrogenic Capacity of Four Adult Stem/Progenitor Cells for Cartilage Cell-Based Repair, Journal of Biomedical Materials Research - Part A (2016)
23. Improved Bone Regeneration Through Amniotic Membrane Loaded With Buccal Fat Pad-Derived Mscs As an Adjuvant in Maxillomandibular Reconstruction, Journal of Cranio-Maxillofacial Surgery (2019)
24. Scanning Electron Microscope Evaluation of Dental Implant Socket Hole: Drilling Versus Osteotome Technique, Journal of Craniofacial Surgery (2016)
25. Staged Reconstruction of Hemimaxillectomy Defect: Application of Buccal Fat Pad Flap, Iliac Bone Graft and Implant-Supported Dental Prostheses, Clinical Case Reports (2020)
26. Therapeutic Application of Multipotent Stem Cells, Journal of Cellular Physiology (2018)
27. Transplantation of Autologous Fat, Stromal Vascular Fraction (Svf) Cell, and Platelet-Rich Plasma (Prp) for Cell Therapy of Atrophic Acne Scars: Clinical Evaluation and Biometric Assessment, Journal of Cosmetic Dermatology (2022)
28. Preclinical and Clinical Studies on the Use of Extracellular Vesicles Derived From Mesenchymal Stem Cells in the Treatment of Chronic Wounds, Molecular Pharmaceutics (2024)
29. Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis, Current Stem Cell Research and Therapy (2016)
30. Rejuvenation of Facial Skin and Improvement in the Dermal Architecture by Transplantation of Autologous Stromal Vascular Fraction: A Clinical Study, BioImpacts (2016)
31. Rhinoplasty With Fillers and Fat Grafting, Oral and Maxillofacial Surgery Clinics of North America (2021)
32. Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges, Molecular Neurobiology (2022)
33. Comparison of Tgf-Β1 and No Production by Mesenchymal Stem Cells Isolated From Murine Lung and Adipose Tissues, Immunopharmacology and Immunotoxicology (2016)
34. Xeno-Free Protocol for Gmp-Compliant Manufacturing of Human Fetal Pancreas-Derived Mesenchymal Stem Cells, Stem Cell Research and Therapy (2022)
35. Apelin and Stem Cells: The Role Played in the Cardiovascular System and Energy Metabolism, Cell Biology International (2019)
36. Therapeutic Role of Mesenchymal Stem Cell-Derived Exosomes in Respiratory Disease, Stem Cell Research and Therapy (2022)
37. Clinical Grade Human Adipose Tissue-Derived Mesenchymal Stem Cell Banking, Acta Medica Iranica (2015)
38. Therapeutic Approach of Adipose-Derived Mesenchymal Stem Cells in Refractory Peptic Ulcer, Stem Cell Research and Therapy (2021)
39. Induced Pluripotent Stem Cells As a New Getaway for Bone Tissue Engineering: A Systematic Review, Cell Proliferation (2017)
40. Fabrication of a Three-Dimensional Β-Tricalcium-Phosphate/Gelatin Containing Chitosan-Based Nanoparticles for Sustained Release of Bone Morphogenetic Protein-2: Implication for Bone Tissue Engineering, Materials Science and Engineering C (2017)
41. Epigenetic Regulation of Specific Transcription Factors in Osteogenic Differentiation of Mesenchymal Stem Cells, Turkish Journal of Biology (2016)
42. Paroxetine Can Enhance Neurogenesis During Neurogenic Differentiation of Human Adipose-Derived Stem Cells, Avicenna Journal of Medical Biotechnology (2016)