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Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (Ianr/Canr Version 2019) Publisher



Huang H1, 2 ; Young W3 ; Skaper S4 ; Chen L5 ; Moviglia G6 ; Saberi H7 ; Alzoubi Z8 ; Sharma HS9 ; Muresanu D10 ; Sharma A11 ; El Masry W12 ; Feng S13
Authors
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Authors Affiliations
  1. 1. Institute of Neurorestoratology, Third Medical Center of PLA General Hospital, Beijing, China
  2. 2. Hongtianji Neuroscience Academy, Lingxiu Building, No.1 at Gucheng Street, Beijing, China
  3. 3. W. M. Keck Center for Collaborative Neuroscience, Rutgers, State University of New Jersey, Piscataway, NJ, United States
  4. 4. Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy
  5. 5. Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China
  6. 6. Center of Research and Engineer of Tissues and Cellular Therapy, Maimonides University, Buenos Aires, Argentina
  7. 7. Department of Neurosurgery, Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Jordan Ortho and Spinal Centre, Al-Saif Medical Center, Amman, Jordan
  9. 9. Intensive Experimental CNS Injury and Repair, University Hospital, Uppsala, University, Uppsala, Sweden
  10. 10. Department of Neurosciences “Iuliu Hatieganu�, University of Medicine and Pharmacy, Cluj-Napoca, Romania
  11. 11. Department of Neurosurgery, LTM Medical College, LTMG Hospital, Mumbai, Mumbai, India
  12. 12. Spinal Injuries Unit, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, United Kingdom
  13. 13. Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, China

Source: Journal of Orthopaedic Translation Published:2020


Abstract

Functional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, “Clinical Therapeutic Guidelines of Neurorestoration for Spinal Cord Injury (China Version 2016)” was first ​proposed in 2016 by the Chinese Association of Neurorestoratology (CANR). Given the rapid advances in this field in recent years, the International Association of Neurorestoratology (IANR) and CANR formed and approved the “Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)”. These guidelines mainly introduce restoring damaged neurological structure and functions by varying neurorestorative strategies in acute, subacute, and chronic phases of SCI. These guidelines can provide a neurorestorative therapeutic standard or reference for clinicians and researchers in clinical practice to maximally restore functions of patients with SCI and improve their quality of life. The translational potential of this article: This guideline provided comprehensive management strategies for SCI, which contains the evaluation and diagnosis, pre-hospital first aid, treatments, rehabilitation training, and complications management. Nowadays, amounts of neurorestorative strategies have been demonstrated to be benefit in promoting the functional recovery and improving the quality of life for SCI patients by clinical trials. Also, the positive results of preclinical research provided lots of new neurorestorative strategies for SCI treatment. These promising neurorestorative strategies are worthy of translation in the future and can promote the advancement of SCI treatments. © 2019 The Authors
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