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Clinical Cell Therapy Guidelines for Neurorestoration (Ianr/Canr 2022) Publisher



Huang H1 ; Al Zoubi ZM2 ; Moviglia G3 ; Sharma HS4 ; Sarnowska A5 ; Sanberg PR6 ; Chen L7 ; Xue Q8 ; Siniscalco D9 ; Feng S10 ; Saberi H11 ; Guo X12 ; Xue M13 ; Dimitrijevic MR14 Show All Authors
Authors
  1. Huang H1
  2. Al Zoubi ZM2
  3. Moviglia G3
  4. Sharma HS4
  5. Sarnowska A5
  6. Sanberg PR6
  7. Chen L7
  8. Xue Q8
  9. Siniscalco D9
  10. Feng S10
  11. Saberi H11
  12. Guo X12
  13. Xue M13
  14. Dimitrijevic MR14
  15. Andrews RJ15
  16. Mao G16
  17. Zhao RC17
  18. Han F18
Show Affiliations
Authors Affiliations
  1. 1. Beijing Hongtianji Neuroscience Academy, Beijing, 100143, China
  2. 2. Jordan Ortho and Spinal Centre, Al-Saif Medical Center, Amman, Jordan
  3. 3. Wake Forest Institute for Regenerative Medicine of Wake Forest University, NC, United States
  4. 4. Intensive Experimental CNS Injury and Repair, University Hospital, Uppsala University, Uppsala, Sweden
  5. 5. Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
  6. 6. Center of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, Florida, 33612, United States
  7. 7. Department of Neurosurgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, 100700, China
  8. 8. Department of Neurology, First Affiliated Hospital of Soochow University, Jiangsu, Suzhou, 215006, China
  9. 9. Department of Experimental Medicine, University of Campania “Luigi Vanvitelli�, Naples, Italy
  10. 10. Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, 300052, China
  11. 11. Department of Neurosurgery, Brain and Spinal Injury Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Neurological Department, 981 Hospital of Chinese PLA, Hebei, Chengde, 067000, China
  13. 13. Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, 450001, China
  14. 14. Baylor College of Medicine, Houston, TX, United States
  15. 15. World Federation of Neurosurgical Societies, Nyon, Switzerland
  16. 16. Department of Neurosurgery, Third Medical Center of General Hospital of PLA, Beijing, 100039, China
  17. 17. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences, Beijing, 100005, China
  18. 18. The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng University / Liaocheng People's Hospital, Shandong, Liaocheng, 252000, China

Source: Journal of Neurorestoratology Published:2022


Abstract

Cell therapy has been shown to be a crucial clinical therapeutic option for central nervous system diseases or damage. Promoting standardization of clinical cell therapy procedures is essential for professional associations devoted to cell therapy. The International Association of Neurorestoratology (IANR) and the Chinese Association of Neurorestoratology (CANR; Preparatory) collaborated to release Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017) in 2018. Due to recent advances and achievements in clinical cell therapy worldwide in recent years, IANR and CANR have renewed and updated the guidelines. Except for the requirements of equipment, personnel, and ethics, these revised guidelines include cell type nomenclature, cell quality control, cell types in clinical application, minimal suggested cellular doses, patient-informed consent, indications and contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, the policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility. IANR/CANR recommends that all clinical practitioners follow these cellular therapy guidelines. These guidelines provide references of better cell types, doses, routes, and therapeutic timing windows in different diseases. © 2022 The Authors
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