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The Trim Proteins in Cancer: From Expression to Emerging Regulatory Mechanisms Publisher Pubmed



Mohammadi A1 ; Pour Abbasi MS2 ; Khorrami S3 ; Khodamoradi S4 ; Mohammadi Goldar Z5 ; Ebrahimzadeh F6
Authors
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Authors Affiliations
  1. 1. Department of Genetics Islamic, Azad University of Marand, Marand, Iran
  2. 2. Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  6. 6. Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Clinical and Translational Oncology Published:2022


Abstract

New clinical evidence suggests that dysregulation of the ubiquitin-mediated destruction of tumor suppressors or oncogene products is probably engaged in the etiology of leukemia and carcinoma. The superfamily of tripartite motif (TRIM)-containing protein family is among the biggest recognized single protein RING finger E3 ubiquitin ligases that are considered vital carcinogenesis regulators, which is not shocking since TRIM proteins are engaged in various biological processes, including cell growth, development, and differentiation; hence, TRIM proteins’ alterations may influence apoptosis, cell proliferation, and transcriptional regulation. In this review article, the various mechanisms through which TRIM proteins exert their role in the most prevalent malignancies including lung, prostate, colorectal, liver, breast, brain cancer, and leukemia are summarized. © 2021, The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO).
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