Comprehensive Analysis of the Role of Ubiquitin-Specific Peptidases in Colorectal Cancer: A Systematic Review Publisher



Albalushi E¹ ; Al Marzouqi A¹ ; Tavoosi S² ; Baghsheikhi AH³ ; Sadri A⁴ ; Aliabadi LS⁵ ; Salarabedi MM⁶ ; Rahman SA¹ ; Alyateem N⁷ ; Jarrahi AM⁸ ; Halimi A⁸ ; Ahmadvand M⁵ ; Abdelrahman WM⁹ Show Affiliations
Source: World Journal of Gastrointestinal Oncology Published:2024

Abstract

BACKGROUND Colorectal cancer (CRC) is the third most frequent and the second most fatal cancer. The search for more effective drugs to treat this disease is ongoing. A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic strategies. Ubiquitin-specific peptidases (USPs), the largest group of the deubiquitinase protein family, have long been implicated in various cancers. There have been numerous studies on the role of USPs in CRC; however, a comprehensive view of this role is lacking. AIM To provide a systematic review of the studies investigating the roles and functions of USPs in CRC. METHODS We systematically queried the MEDLINE (via PubMed), Scopus, and Web of Science databases. RESULTS Our study highlights the pivotal role of various USPs in several processes implicated in CRC: Regulation of the cell cycle, apoptosis, cancer stemness, epithelial–mesenchymal transition, metastasis, DNA repair, and drug resistance. The findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in CRC. The dysregulation of USPs in CRC contributes to drug resistance through multiple mechanisms. CONCLUSION Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC. © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.