Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Sericin Alleviates Motor Dysfunction by Modulating Inflammation and Trkb/Bdnf Signaling Pathway in the Rotenone-Induced Parkinson’S Disease Model Publisher Pubmed



Salari Z1 ; Ashabi G2 ; Fartoosi A1 ; Fartoosi A1 ; Shariatpanahi M1 ; Aghsami M1 ; Montazeri H3 ; Kheradmand A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, P.O. box: 1475886671, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran

Source: BMC Pharmacology and Toxicology Published:2023


Abstract

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of nigrostriatal dopaminergic neurons and movement impairment. Based on theories, neuroinflammatory processes may be vital in the etiology of PD and other neurodegenerative diseases. Reports show that rotenone has neurotoxic, inflammatory, and motor impairment effects in PD. Sericin is a natural polymer with effective properties, such as neuroprotective and anti-inflammatory. Therefore, this study aimed to examine the effects of sericin administration on motor dysfunction by modulating inflammation and tyrosine kinase B/brain-derived neurotrophic factor (TrkB/BDNF) pathway in the rotenone-induced PD model. Methods: Wistar male rats (3-months-old) were treated with rotenone (2 mg/kg every 48 h for 30 days) to induce a rotenone-induced PD model. Also, sericin was administered orally at dose of 200 mg/kg every 48 h for 30 days. Rotarod and bar tests were performed for motor dysfunction. The protein levels of BDNF, c-fos, TrkB, tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6) and catalase activity were evaluated in the striatum area. Results: Results showed that sericin increased latent time in the rotarod test and decreased the time staying on the pole in the bar test compared to the PD group (P < 0.001 for both tests). Moreover, sericin treatments decreased TNF-α (P < 0.001) and IL-6 (P < 0.001) concentration levels and enhanced the levels of BDNF (P < 0.001), c-fos (P < 0.001), TrkB (P < 0.001) proteins and catalase activity (P < 0.05) in the striatum area compared to the PD group. Conclusion: These results support a protective benefit of sericin therapy in a rotenone-induced PD paradigm by reducing motor impairment, inflammatory response, and disruption of the TrkB/BDNF signaling pathway. © 2023, The Author(s).
Related Docs
View other Related Docs
1. Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and Susceptibility to Schizophrenia, Parkinson’S and Alzheimer’S Diseases, Current Gene Therapy (2018)
2. Plasma Levels of Brain-Derived Neurotrophic Factor in Patients With Parkinson Disease: A Systematic Review and Meta-Analysis, Brain Research (2019)
3. Bombyx Mori Cocoon As a Promising Pharmacological Agent: A Review of Ethnopharmacology, Chemistry, and Biological Activities, Heliyon (2022)
4. Understanding the Neurobiological Mechanisms of Lps-Induced Memory Impairment, Acta Neurobiologiae Experimentalis (2024)
5. A Camp Analog Attenuates Beta-Amyloid (1–42)-Induced Mitochondrial Dysfunction and Spatial Learning and Memory Deficits, Brain Research Bulletin (2018)
6. Bucladesine Attenuates Spatial Learning and Hippocampal Mitochondrial Impairments Induced by 3, 4-Methylenedioxymethamphetamine (Mdma), Neurotoxicity Research (2020)
7. Ferulic Acid, a Phenolic Compound With Therapeutic Effects in Neuropsychiatric Disorders, Stimulates the Production of Nerve Growth Factor and Endocannabinoids in Rat Brain, Physiology and Pharmacology (Iran) (2017)
8. Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease, Basic and Clinical Neuroscience (2021)
Experts (# of related papers)
View all Related Experts
Mohammad Sharifzadeh (8)
Fatemeh Atyabi (4)
Other Related Docs
9. Assessment of Lipophilic Fluorescence Products in Β-Amyloid-Induced Cognitive Decline: A Parallel Track in Hippocampus, Csf, Plasma and Erythrocytes, Experimental Gerontology (2022)
10. Fluoxetine Attenuates Stress-Induced Depressive-Like Behavior Through Modulation of Hippocampal Gap43 and Neurogenesis in Male Rats, Journal of Chemical Neuroanatomy (2020)
11. Evaluation of Hippocampal Arylalkylamine N-Acetyltransferase Activity in Amyloid-Β Neurotoxicity, Journal of Molecular Endocrinology (2023)
12. The Effect of a Nicotine-Rich Diet With/Without Redistribution of Dietary Protein on Motor Indices in Patients With Parkinson's Disease: A Randomized Clinical Trial, Journal of Clinical Neuroscience (2024)
13. Pelargonidin Improves Memory Deficit in Amyloid Β25-35 Rat Model of Alzheimer's Disease by Inhibition of Glial Activation, Cholinesterase, and Oxidative Stress, Biomedicine and Pharmacotherapy (2016)
14. Application of Nanostructured Lipid Carriers: The Prolonged Protective Effects for Sesamol in in Vitro and in Vivo Models of Ischemic Stroke Via Activation of Pi3k Signalling Pathway, DARU# Journal of Pharmaceutical Sciences (2017)
15. Ameliorating of Memory Impairment and Apoptosis in Amyloid Β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy, Iranian Journal of Pharmaceutical Research (2015)
16. Effects of Mercuric Chloride on Spatial Memory Deficit-Induced by Beta-Amyloid and Evaluation of Mitochondrial Function Markers in the Hippocampus of Rats, Metallomics (2020)
17. Protective Effects of Salicylate on Pka Inhibitor (H-89)-Induced Spatial Memory Deficit Via Lessening Autophagy and Apoptosis in Rats, Pharmacology Biochemistry and Behavior (2016)
18. Sesamin Imparts Neuroprotection Against Intrastriatal 6-Hydroxydopamine Toxicity by Inhibition of Astroglial Activation, Apoptosis, and Oxidative Stress, Biomedicine and Pharmacotherapy (2017)
19. Dietary Uptake of Salvia Macilenta Extract Improves Nrf2 Antioxidant Signaling Pathway and Diminishes Inflammation and Apoptosis in Amyloid Beta-Induced Rats, Molecular Biology Reports (2021)
20. Aerobic Training With Naringin Supplementation Improved Spatial Cognition Via H2s Signaling Pathway in Alzheimer’S Disease Model Rats, Experimental Aging Research (2023)
21. Ovarian Hormones Prevent Methamphetamine-Induced Anxiety-Related Behaviors and Neuronal Damage in Ovariectomized Rats, Neuroscience Letters (2021)
22. The Endocannabinoid System and Ngf Are Involved in the Mechanism of Action of Resveratrol: A Multi-Target Nutraceutical With Therapeutic Potential in Neuropsychiatric Disorders, Psychopharmacology (2016)
23. Neuroprotective Effects of Cerium Oxide Nanoparticles on Experimental Stress-Induced Depression in Male Rats, Journal of Chemical Neuroanatomy (2020)
24. Satureja Bachtiarica Ameliorate Beta-Amyloid Induced Memory Impairment, Oxidative Stress and Cholinergic Deficit in Animal Model of Alzheimer’S Disease, Metabolic Brain Disease (2016)
25. Immune-Mediated Cognition Impairment in Multiple Sclerosis, Translational Neuroimmunology: Multiple Sclerosis: Volume 8 (2023)
26. Rosmarinic Acid Exerts a Neuroprotective Effect in the Kainate Rat Model of Temporal Lobe Epilepsy: Underlying Mechanisms, Pharmaceutical Biology (2015)
27. Neuroprotective Effect of New Nanochelating-Based Nano Complex, Alzc3, Against Aβ (1–42)-Induced Toxicity in Rat: A Comparison With Memantine, Pharmaceutical Research (2020)
28. The 40-Hz White Light-Emitting Diode (Led) Improves the Structure–Function of the Brain Mitochondrial Katp Channel and Respiratory Chain Activities in Amyloid Beta Toxicity, Molecular Neurobiology (2022)
29. Effects of Quercetin Against Fluoride-Induced Neurotoxicity in the Medial Prefrontal Cortex of Rats: A Stereological, Histochemical and Behavioral Study, Food and Chemical Toxicology (2025)
30. Ferulic Acid Attenuates Kainate-Induced Neurodegeneration in a Rat Poststatus Epilepticus Model, Current Molecular Pharmacology (2023)
31. Ferulic Acid-Loaded Nanostructured Lipid Carriers: A Promising Nanoformulation Against the Ischemic Neural Injuries, Life Sciences (2018)
32. How Sodium Arsenite Improve Amyloid Β-Induced Memory Deficit?, Physiology and Behavior (2016)
33. Assessment of the Protective Effect of Kn-93 Drug in Systemic Epilepsy Disorders Induced by Pilocarpine in Male Rat, Journal of Cellular Biochemistry (2019)
34. Pre- and Post-Treatment of Α-Tocopherol on Cognitive, Synaptic Plasticity, and Mitochondrial Disorders of the Hippocampus in Icv-Streptozotocin-Induced Sporadic Alzheimer’S-Like Disease in Male Wistar Rat, Frontiers in Neuroscience (2023)
35. Naringenin Improves Learning and Memory in an Alzheimer's Disease Rat Model: Insights Into the Underlying Mechanisms, European Journal of Pharmacology (2015)
36. Impact of Green-Synthesized Silver Nanoparticles on Cognitive Function and Fluorescence Spectroscopy of Redox Status in the Hippocampus, Nanomedicine Research Journal (2022)
37. Geldanamycin Reduces Aβ-Associated Anxiety and Depression, Concurrent With Autophagy Provocation, Journal of Molecular Neuroscience (2015)
38. Melatonin Reverses H-89 Induced Spatial Memory Deficit: Involvement of Oxidative Stress and Mitochondrial Function, Behavioural Brain Research (2017)
39. Brain Region Specificity of Mitochondrial Biogenesis and Bioenergetics Response to Nrf2 Knockdown: A Comparison Among Hippocampus, Prefrontal Cortex and Amygdala of Male Rat Brain, Brazilian Archives of Biology and Technology (2017)
40. Autism-Like Symptoms by Exposure to Air Pollution and Valproic Acid–Induced in Male Rats, Environmental Science and Pollution Research (2022)