Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells

Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells Publisher Pubmed

Farani MR¹ ; Parsi PK¹ ; Riazi G² ; Ardestani MS³ ; Rad HS^{4, 5}

Show Affiliations

1. School of Chemical Engineering, University College of Engineering, University of Tehran, Tehran, 4563-11155, Iran
2. Institute of Biophysics and Biochemistry, University of Tehran, Tehran, 1417614411, Iran
3. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Quantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
5. Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran

Source: Drug Design# Development and Therapy Published:2019

Abstract

Objective: In this study, novel graphene oxide (GO)-based nanocomposites are presented. In fact, we have tried to replace the carboxyl groups on the surface of GO with amine groups to allow the biocompatible poly(ethylene glycol) bis(carboxymethyl) ether (average Mn 600) polymer to bond through an amide bond. Materials and methods: The synthesis was conducted accurately according to final characterization experiments (Raman, X-ray diffraction [XRD], atomic force microscopy [AFM], X-ray photoelectron spectroscopy [XPS], thermogravimetric analysis [TGA], etc). The antimicrobial property of this nanocomposite was examined in Escherichia coli (ATCC 25922) as Gram-negative and Staphylococcus aureus (ATCC 25923) as Gram-positive bacterial species. Besides, curcumin (CUR) was added to the produced nanocomposite both as a promising anticancer drug and an antioxidant, the toxicity of which was then assessed on cellular-based HepG2 and pC12. Results: An intense increase in toxicity was detected by MTT assay. Conclusion: It can mainly be concluded that the nanocomposite synthesized in this study is capable of delivering drugs with antibacterial properties. © 2019 Ramezani Farani et al.

2. Evaluation of the Photothermal Properties of a Reduced Graphene Oxide/Arginine Nanostructure for Near-Infrared Absorption, ACS Applied Materials and Interfaces (2017)

3. Codelivery of Hydrophobic and Hydrophilic Drugs by Graphene-Decorated Magnetic Dendrimers, Langmuir (2018)

4. Graphene Aerogel Nanoparticles for In-Situ Loading/Ph Sensitive Releasing Anticancer Drugs, Colloids and Surfaces B: Biointerfaces (2020)

5. Systems Toxicology Assessment Revealed the Impact of Graphene-Based Materials on Cell Cycle Regulators, Journal of Biomedical Materials Research - Part A (2020)

6. Nanofibrillated Chitosan Coated Highly Ordered Titania Nanotubes Array/Graphene Nanocomposite With Improved Biological Characters, Carbohydrate Polymers (2021)

Experts (# of related papers)

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Mohammad Ali Mohagheghi (1)

Mehdi Shafee Ardestani (1)

Style	Citing Format
MLA	Farani MR, et al.. "Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells." Drug Design# Development and Therapy, vol. 13, no. , 2019, pp. 1581-1591.
APA	Farani MR, Parsi PK, Riazi G, Ardestani MS, Rad HS (2019). Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells. Drug Design# Development and Therapy, 13(), 1581-1591.
Chicago	Farani MR, Parsi PK, Riazi G, Ardestani MS, Rad HS. "Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells." Drug Design# Development and Therapy 13, no. (2019): 1581-1591.
Harvard	Farani MR et al. (2019) 'Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells', Drug Design# Development and Therapy, 13(), pp. 1581-1591.
Vancouver	Farani MR, Parsi PK, Riazi G, Ardestani MS, Rad HS. Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells. Drug Design# Development and Therapy. 2019;13():1581-1591.
BibTex	@article{ author = {Farani MR and Parsi PK and Riazi G and Ardestani MS and Rad HS}, title = {Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells}, journal = {Drug Design# Development and Therapy}, volume = {13}, number = {}, pages = {1581-1591}, year = {2019} }
RIS	TY - JOUR AU - Farani MR AU - Parsi PK AU - Riazi G AU - Ardestani MS AU - Rad HS TI - Extending the Application of a Magnetic Peg Three-Part Drug Release Device on a Graphene Substrate for the Removal of Gram-Positive and Gram-Negative Bacteria and Cancerous and Pathologic Cells JO - Drug Design# Development and Therapy VL - 13 IS - SP - 1581 EP - 1591 PY - 2019 ER -

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Abstract